Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect
Fluoxetine is one of the most commonly used antidepressants, classified under selective serotonin reuptake inhibitors (SSRIs). It is indicated for the treatment of depression, obsessive-compulsive disorder, anxiety, and eating disorders. The antidepressant effect of fluoxetine is achieved by inhibit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Industrial Psychiatry Journal |
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| Online Access: | https://journals.lww.com/10.4103/ipj.ipj_326_24 |
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| _version_ | 1849314976016105472 |
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| author | Barath Ramanathan Souganya Vijayan Perarul Sivakumar Arun Selvaraj |
| author_facet | Barath Ramanathan Souganya Vijayan Perarul Sivakumar Arun Selvaraj |
| author_sort | Barath Ramanathan |
| collection | DOAJ |
| description | Fluoxetine is one of the most commonly used antidepressants, classified under selective serotonin reuptake inhibitors (SSRIs). It is indicated for the treatment of depression, obsessive-compulsive disorder, anxiety, and eating disorders. The antidepressant effect of fluoxetine is achieved by inhibiting the reuptake of serotonin (5-HT) via the serotonin transporter (SERT) in neurons. Although fluoxetine is generally considered safe and well-tolerated by most patients, this case series describes instances where patients treated with fluoxetine subsequently developed menstrual irregularities. Upon discontinuation of fluoxetine, the menstrual cycles returned to normal. To the best of our knowledge, there is a lack of precise data associating fluoxetine with the onset of menstrual irregularities. This effect may be related to its central serotonergic action via 5-HT action modulates the prolactin, estradiol, and progesterone level. Therefore, physicians should be aware of the potential risk of fluoxetine-induced menstrual irregularities. |
| format | Article |
| id | doaj-art-290eef4de7c141b8a93187d2c1e4e292 |
| institution | Kabale University |
| issn | 0972-6748 0976-2795 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Industrial Psychiatry Journal |
| spelling | doaj-art-290eef4de7c141b8a93187d2c1e4e2922025-08-20T03:52:16ZengWolters Kluwer Medknow PublicationsIndustrial Psychiatry Journal0972-67480976-27952025-01-0134112612910.4103/ipj.ipj_326_24Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effectBarath RamanathanSouganya VijayanPerarul SivakumarArun SelvarajFluoxetine is one of the most commonly used antidepressants, classified under selective serotonin reuptake inhibitors (SSRIs). It is indicated for the treatment of depression, obsessive-compulsive disorder, anxiety, and eating disorders. The antidepressant effect of fluoxetine is achieved by inhibiting the reuptake of serotonin (5-HT) via the serotonin transporter (SERT) in neurons. Although fluoxetine is generally considered safe and well-tolerated by most patients, this case series describes instances where patients treated with fluoxetine subsequently developed menstrual irregularities. Upon discontinuation of fluoxetine, the menstrual cycles returned to normal. To the best of our knowledge, there is a lack of precise data associating fluoxetine with the onset of menstrual irregularities. This effect may be related to its central serotonergic action via 5-HT action modulates the prolactin, estradiol, and progesterone level. Therefore, physicians should be aware of the potential risk of fluoxetine-induced menstrual irregularities.https://journals.lww.com/10.4103/ipj.ipj_326_24fluoxetinemensural irregularitiesssri |
| spellingShingle | Barath Ramanathan Souganya Vijayan Perarul Sivakumar Arun Selvaraj Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect Industrial Psychiatry Journal fluoxetine mensural irregularities ssri |
| title | Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect |
| title_full | Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect |
| title_fullStr | Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect |
| title_full_unstemmed | Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect |
| title_short | Fluoxetine brakes the menstrual cycle: Uncovering the unexpected effect |
| title_sort | fluoxetine brakes the menstrual cycle uncovering the unexpected effect |
| topic | fluoxetine mensural irregularities ssri |
| url | https://journals.lww.com/10.4103/ipj.ipj_326_24 |
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