Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100
We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of ac...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/942517 |
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| author | Víctor Toledano Enrique Hernández-Jiménez Carolina Cubillos-Zapata Marta Flandez Enrique Álvarez Aníbal Varela-Serrano Ramón Cantero Gema Valles Francisco García-Rio Eduardo López-Collazo |
| author_facet | Víctor Toledano Enrique Hernández-Jiménez Carolina Cubillos-Zapata Marta Flandez Enrique Álvarez Aníbal Varela-Serrano Ramón Cantero Gema Valles Francisco García-Rio Eduardo López-Collazo |
| author_sort | Víctor Toledano |
| collection | DOAJ |
| description | We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required. |
| format | Article |
| id | doaj-art-290e519d42e7487bbbe9248132565fa1 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-290e519d42e7487bbbe9248132565fa12025-08-20T02:03:52ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/942517942517Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100Víctor Toledano0Enrique Hernández-Jiménez1Carolina Cubillos-Zapata2Marta Flandez3Enrique Álvarez4Aníbal Varela-Serrano5Ramón Cantero6Gema Valles7Francisco García-Rio8Eduardo López-Collazo9Tumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainTumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainTumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainTumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainInnate Immunity Group, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainTumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainInnate Immunity Group, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainCIBER-BBN, 28029 Madrid, SpainRespiratory Disease, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainTumor Immunology Laboratory, IdiPAZ, La Paz Hospital, 28046 Madrid, SpainWe show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required.http://dx.doi.org/10.1155/2015/942517 |
| spellingShingle | Víctor Toledano Enrique Hernández-Jiménez Carolina Cubillos-Zapata Marta Flandez Enrique Álvarez Aníbal Varela-Serrano Ramón Cantero Gema Valles Francisco García-Rio Eduardo López-Collazo Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100 Mediators of Inflammation |
| title | Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100 |
| title_full | Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100 |
| title_fullStr | Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100 |
| title_full_unstemmed | Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100 |
| title_short | Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100 |
| title_sort | galactomannan downregulates the inflammation responses in human macrophages via nfκb2 p100 |
| url | http://dx.doi.org/10.1155/2015/942517 |
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