Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection associated with significant morbidity and can be fatal if left unrecognized. A retrospective multicentric study was carried out at five tertiary ca...
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Jaypee Brothers Medical Publisher
2023-06-01
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| Series: | Pediatric Infectious Disease |
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| Online Access: | https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1390 |
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| author | Sagar Bhattad Ramya Sadashiva Rachna S Mohite Karthik Arigela Syed M Naushad Jeeson Unni Rajappan Pillai Gladys Cyril George Paul Suresh Kumar Sathish Kumar Manjula Anand Vinitha Anirudhan Sujatha Thyagarajan Sangeetha Budur Sindhu Malvel Jyothi Raghuram Srinivasa Murthy Lathiesh Kumar Arun Kumar Chetan Ginigeri |
| author_facet | Sagar Bhattad Ramya Sadashiva Rachna S Mohite Karthik Arigela Syed M Naushad Jeeson Unni Rajappan Pillai Gladys Cyril George Paul Suresh Kumar Sathish Kumar Manjula Anand Vinitha Anirudhan Sujatha Thyagarajan Sangeetha Budur Sindhu Malvel Jyothi Raghuram Srinivasa Murthy Lathiesh Kumar Arun Kumar Chetan Ginigeri |
| author_sort | Sagar Bhattad |
| collection | DOAJ |
| description | Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection associated with significant morbidity and can be fatal if left unrecognized.
A retrospective multicentric study was carried out at five tertiary care centers in South India, to evaluate the clinical profile of children admitted with MIS-C associated with SARS-CoV-2 infection. Cases of MIS-C diagnosed during October 2020 to December 2021 were included. Diagnosis of MIS-C was based on World Health Organization (WHO) criteria. All children underwent echocardiography at admission, discharge, and 4–6 weeks of follow-up. Children with MIS-C were treated with intravenous immunoglobulin (IVIG) and/or steroids. We compared younger children (<5 years of age) with older ones to determine if age at presentation could predict severity in children with MIS-C. A total of 81 children were diagnosed to have MIS-C during the study period. The mean age of presentation was 6.8 years. Around 29.6% of the children had a shock at admission and 54.3% had myocardial dysfunction. The average duration of a pediatric intensive care unit (PICU) stay was 6.6 days. Anti-SARS-CoV-2 antibodies were found to be positive in 75.3% of patients. Children with high N-terminal prohormone of brain natriuretic peptide (NT-proBNP) had more severe presentations. All children responded promptly to IVIG and steroids and the mortality was 0%. No difference was noted in terms of outcome between younger (<5 years) and older children. A significant proportion of children with MIS-C present with shock and myocardial dysfunction. Anti-SARS-CoV-2 antibodies were positive in 75% of children whose primary infection went unnoticed. We hereby report one of the largest cohorts of MIS-C patients from the Indian subcontinent. |
| format | Article |
| id | doaj-art-2909fb6df63e44f2b87e341e90873edb |
| institution | DOAJ |
| issn | 2582-4988 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Pediatric Infectious Disease |
| spelling | doaj-art-2909fb6df63e44f2b87e341e90873edb2025-08-20T02:56:45ZengJaypee Brothers Medical PublisherPediatric Infectious Disease2582-49882023-06-0152374110.5005/jp-journals-10081-13901Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South IndiaSagar Bhattad0Ramya Sadashiva1Rachna S Mohite2Karthik Arigela3Syed M Naushad4Jeeson Unni5Rajappan Pillai6Gladys Cyril7George Paul8Suresh Kumar9Sathish Kumar10Manjula Anand11Vinitha Anirudhan12Sujatha Thyagarajan13Sangeetha Budur14Sindhu Malvel15Jyothi Raghuram16Srinivasa Murthy17Lathiesh Kumar18Arun Kumar19Chetan Ginigeri20Sagar Bhattad, Department of Pediatrics, Aster CMI Hospital, Bengaluru, Karnataka, India, Phone: +91 9779433934Department of Pediatrics, Aster CMI Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster CMI Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster CMI Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster CMI Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster Medcity Hospital, Kochi, Kerala, IndiaDepartment of Pediatrics, Aster Medcity Hospital, Kochi, Kerala, IndiaDepartment of Pediatrics, Aster Medcity Hospital, Kochi, Kerala, IndiaDepartment of Pediatrics, Aster Medcity Hospital, Kochi, Kerala, IndiaDepartment of Pediatrics, Aster MIMS Hospital, Calicut, Kerala, IndiaDepartment of Pediatrics, Aster MIMS Hospital, Calicut, Kerala, IndiaDepartment of Pediatrics, Aster MIMS Hospital, Calicut, Kerala, IndiaDepartment of Pediatrics, Aster MIMS Hospital, Calicut, Kerala, IndiaDepartment of Pediatrics, Aster RV Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster RV Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster RV Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster Women & Children Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster Women & Children Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster Women & Children Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster Women & Children Hospital, Bengaluru, Karnataka, IndiaDepartment of Pediatrics, Aster CMI Hospital, Bengaluru, Karnataka, IndiaMultisystem inflammatory syndrome in children (MIS-C) is a severe complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection associated with significant morbidity and can be fatal if left unrecognized. A retrospective multicentric study was carried out at five tertiary care centers in South India, to evaluate the clinical profile of children admitted with MIS-C associated with SARS-CoV-2 infection. Cases of MIS-C diagnosed during October 2020 to December 2021 were included. Diagnosis of MIS-C was based on World Health Organization (WHO) criteria. All children underwent echocardiography at admission, discharge, and 4–6 weeks of follow-up. Children with MIS-C were treated with intravenous immunoglobulin (IVIG) and/or steroids. We compared younger children (<5 years of age) with older ones to determine if age at presentation could predict severity in children with MIS-C. A total of 81 children were diagnosed to have MIS-C during the study period. The mean age of presentation was 6.8 years. Around 29.6% of the children had a shock at admission and 54.3% had myocardial dysfunction. The average duration of a pediatric intensive care unit (PICU) stay was 6.6 days. Anti-SARS-CoV-2 antibodies were found to be positive in 75.3% of patients. Children with high N-terminal prohormone of brain natriuretic peptide (NT-proBNP) had more severe presentations. All children responded promptly to IVIG and steroids and the mortality was 0%. No difference was noted in terms of outcome between younger (<5 years) and older children. A significant proportion of children with MIS-C present with shock and myocardial dysfunction. Anti-SARS-CoV-2 antibodies were positive in 75% of children whose primary infection went unnoticed. We hereby report one of the largest cohorts of MIS-C patients from the Indian subcontinent.https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1390anti-severe complication of severe acute respiratory syndrome coronavirus 2 antibodiescoronavirus disease 2019intravenous immunoglobulinmultisystem inflammatory syndrome in childrenmyocardial dysfunctionkawasaki disease |
| spellingShingle | Sagar Bhattad Ramya Sadashiva Rachna S Mohite Karthik Arigela Syed M Naushad Jeeson Unni Rajappan Pillai Gladys Cyril George Paul Suresh Kumar Sathish Kumar Manjula Anand Vinitha Anirudhan Sujatha Thyagarajan Sangeetha Budur Sindhu Malvel Jyothi Raghuram Srinivasa Murthy Lathiesh Kumar Arun Kumar Chetan Ginigeri Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India Pediatric Infectious Disease anti-severe complication of severe acute respiratory syndrome coronavirus 2 antibodies coronavirus disease 2019 intravenous immunoglobulin multisystem inflammatory syndrome in children myocardial dysfunction kawasaki disease |
| title | Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India |
| title_full | Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India |
| title_fullStr | Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India |
| title_full_unstemmed | Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India |
| title_short | Profile of Multisystem Inflammatory Syndrome in Children related to COVID-19: A Multicentric Study from South India |
| title_sort | profile of multisystem inflammatory syndrome in children related to covid 19 a multicentric study from south india |
| topic | anti-severe complication of severe acute respiratory syndrome coronavirus 2 antibodies coronavirus disease 2019 intravenous immunoglobulin multisystem inflammatory syndrome in children myocardial dysfunction kawasaki disease |
| url | https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1390 |
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