The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals
<b>Introduction:</b> During the formation of neural circuits, the developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivota...
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MDPI AG
2024-10-01
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| Series: | Endocrines |
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| Online Access: | https://www.mdpi.com/2673-396X/5/4/36 |
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| author | Nuha Ahmad Dsouki Bruno Fiorelini Pereira Roberta Goes da Silva Vinicius Gonçalves Rodrigues Rafaella da Silva Brito Marina Malta Letro Kizys Maria Izabel Chiamolera Rui Monteiro Maciel Caroline Serrano-Nascimento Gisele Giannocco |
| author_facet | Nuha Ahmad Dsouki Bruno Fiorelini Pereira Roberta Goes da Silva Vinicius Gonçalves Rodrigues Rafaella da Silva Brito Marina Malta Letro Kizys Maria Izabel Chiamolera Rui Monteiro Maciel Caroline Serrano-Nascimento Gisele Giannocco |
| author_sort | Nuha Ahmad Dsouki |
| collection | DOAJ |
| description | <b>Introduction:</b> During the formation of neural circuits, the developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivotal role in maintaining hormonal balance and guiding brain development. However, emerging threats like endocrine-disrupting chemicals (EDCs) can interfere with this intricate system. EDCs are exogenous substances that can mimic, enhance, or block the actions of endogenous hormones, disrupting hormonal signaling in the brain at various developmental stages. Exposure can impair cognitive function and behavior due to disruptions in thyroid function. Studies indicate that mixtures of EDCs negatively impact brain development, leading to lower IQ and behavioral problems. Reducing EDC exposure through regulations and public awareness is crucial, and further research is needed to elucidate their mechanisms. <b>Conclusions:</b> Protecting vulnerable populations, such as pregnant women and children, is essential through prompt regulatory measures. |
| format | Article |
| id | doaj-art-29084353c97c4703b2ecf5ec43a9d7dd |
| institution | DOAJ |
| issn | 2673-396X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj-art-29084353c97c4703b2ecf5ec43a9d7dd2025-08-20T02:43:29ZengMDPI AGEndocrines2673-396X2024-10-015450151510.3390/endocrines5040036The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting ChemicalsNuha Ahmad Dsouki0Bruno Fiorelini Pereira1Roberta Goes da Silva2Vinicius Gonçalves Rodrigues3Rafaella da Silva Brito4Marina Malta Letro Kizys5Maria Izabel Chiamolera6Rui Monteiro Maciel7Caroline Serrano-Nascimento8Gisele Giannocco9Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, BrazilLaboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo 04039-032, SP, Brazil<b>Introduction:</b> During the formation of neural circuits, the developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivotal role in maintaining hormonal balance and guiding brain development. However, emerging threats like endocrine-disrupting chemicals (EDCs) can interfere with this intricate system. EDCs are exogenous substances that can mimic, enhance, or block the actions of endogenous hormones, disrupting hormonal signaling in the brain at various developmental stages. Exposure can impair cognitive function and behavior due to disruptions in thyroid function. Studies indicate that mixtures of EDCs negatively impact brain development, leading to lower IQ and behavioral problems. Reducing EDC exposure through regulations and public awareness is crucial, and further research is needed to elucidate their mechanisms. <b>Conclusions:</b> Protecting vulnerable populations, such as pregnant women and children, is essential through prompt regulatory measures.https://www.mdpi.com/2673-396X/5/4/36mammal brainthyroid hormonesendocrine-disrupting chemicals |
| spellingShingle | Nuha Ahmad Dsouki Bruno Fiorelini Pereira Roberta Goes da Silva Vinicius Gonçalves Rodrigues Rafaella da Silva Brito Marina Malta Letro Kizys Maria Izabel Chiamolera Rui Monteiro Maciel Caroline Serrano-Nascimento Gisele Giannocco The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals Endocrines mammal brain thyroid hormones endocrine-disrupting chemicals |
| title | The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals |
| title_full | The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals |
| title_fullStr | The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals |
| title_full_unstemmed | The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals |
| title_short | The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals |
| title_sort | interplay of the mammalian brain and thyroid hormones and the threat of endocrine disrupting chemicals |
| topic | mammal brain thyroid hormones endocrine-disrupting chemicals |
| url | https://www.mdpi.com/2673-396X/5/4/36 |
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