Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer
Abstract Lung cancer is one of the most commonly diagnosed cancers worldwide and the leading cause of cancer-related deaths worldwide. In recent years, an increasing number of studies have shown that the tumor immune microenvironment (TIME) has a significant impact on the development of lung cancer....
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-01868-5 |
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| author | Huan Cheng Yajiao Shao Ao Zhang Caixia Li Xinxin Li Yuxin Fu Jian Ming |
| author_facet | Huan Cheng Yajiao Shao Ao Zhang Caixia Li Xinxin Li Yuxin Fu Jian Ming |
| author_sort | Huan Cheng |
| collection | DOAJ |
| description | Abstract Lung cancer is one of the most commonly diagnosed cancers worldwide and the leading cause of cancer-related deaths worldwide. In recent years, an increasing number of studies have shown that the tumor immune microenvironment (TIME) has a significant impact on the development of lung cancer. Interleukin-7 (IL-7) is an essential cytokine for the adaptive immune system and plays an important immunoregulatory role in different types of tumors. However, the relationship between IL-7 and TIME in non-small cell lung cancer (NSCLC) is not yet known. This study found that the expression of MCP-1 and CD11b was correlated with the expression of IL-7/IL-7R. MCP-1, IL-7R, tumor differentiation and tumor stage were the strongest predictors of survival. In addition, IL-7 upregulates MCP-1 through JAK1/STAT3 pathway to affect the migration of MDSCs and exert tumor immunosuppressive effect. Furthermore, CCR2 inhibitor and depletion of MDSCs suppressed the promoting effect of IL-7 mediated development of lung cancer. These findings provided the important mechanism that IL-7 upregulate MCP-1 through JAK1/STAT3 pathway to recruit MDSCs and put forth blockage of CCR2 inhibitor and MDSCs recruitment as a prospective immunotherapy strategy for the treatment of NSCLC. |
| format | Article |
| id | doaj-art-290817292c03460f93dee8e9aad9aecd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-290817292c03460f93dee8e9aad9aecd2025-08-20T03:45:59ZengNature PortfolioScientific Reports2045-23222025-05-0115111710.1038/s41598-025-01868-5Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancerHuan Cheng0Yajiao Shao1Ao Zhang2Caixia Li3Xinxin Li4Yuxin Fu5Jian Ming6Department of Pathology, General Hospital of Northern Theater CommandDepartment of Pathology, General Hospital of Northern Theater CommandDepartment of Pathology, General Hospital of Northern Theater CommandDepartment of Pathology, General Hospital of Northern Theater CommandDepartment of Pathology, General Hospital of Northern Theater CommandDepartment of Pathology, General Hospital of Northern Theater CommandDepartment of Pathology, General Hospital of Northern Theater CommandAbstract Lung cancer is one of the most commonly diagnosed cancers worldwide and the leading cause of cancer-related deaths worldwide. In recent years, an increasing number of studies have shown that the tumor immune microenvironment (TIME) has a significant impact on the development of lung cancer. Interleukin-7 (IL-7) is an essential cytokine for the adaptive immune system and plays an important immunoregulatory role in different types of tumors. However, the relationship between IL-7 and TIME in non-small cell lung cancer (NSCLC) is not yet known. This study found that the expression of MCP-1 and CD11b was correlated with the expression of IL-7/IL-7R. MCP-1, IL-7R, tumor differentiation and tumor stage were the strongest predictors of survival. In addition, IL-7 upregulates MCP-1 through JAK1/STAT3 pathway to affect the migration of MDSCs and exert tumor immunosuppressive effect. Furthermore, CCR2 inhibitor and depletion of MDSCs suppressed the promoting effect of IL-7 mediated development of lung cancer. These findings provided the important mechanism that IL-7 upregulate MCP-1 through JAK1/STAT3 pathway to recruit MDSCs and put forth blockage of CCR2 inhibitor and MDSCs recruitment as a prospective immunotherapy strategy for the treatment of NSCLC.https://doi.org/10.1038/s41598-025-01868-5IL-7MDSCsMCP-1NSCLC |
| spellingShingle | Huan Cheng Yajiao Shao Ao Zhang Caixia Li Xinxin Li Yuxin Fu Jian Ming Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer Scientific Reports IL-7 MDSCs MCP-1 NSCLC |
| title | Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer |
| title_full | Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer |
| title_fullStr | Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer |
| title_full_unstemmed | Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer |
| title_short | Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer |
| title_sort | interleukin 7 enhances recruitment of mdscs by regulating mcp 1 via jak1 stat3 signaling pathway in non small cell lung cancer |
| topic | IL-7 MDSCs MCP-1 NSCLC |
| url | https://doi.org/10.1038/s41598-025-01868-5 |
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