NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis

NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis

Abstract Never in mitosis gene A (NIMA)-related kinase 2 (NEK2), a member of the serine-threonine kinase family, is critically involved in the regulation of the cell cycle. Upregulation of NEK2 is associated with aberrant B cell proliferation, a phenomenon potentially driven by NEK2-mediated disrupt...

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Bibliographic Details
Main Authors: Si-Ting Wu, Tian-Xiang Zhang, Zhirui Liu, Xueting An, Xiaoshan Du, Shu Yang, Ti Wu, Guanju Di, Jingshi Song, Bin Feng, Chunyang Wang, Chao Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
NEK2
Multiple sclerosis
Experimental autoimmune encephalomyelitis
B cells
Online Access:https://doi.org/10.1186/s12974-025-03472-w
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