Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit
<b>Aim: </b>The aim of this study was to evaluate histopathologically the therapeutic effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate) injections in rabbits achill tendinopathies induced by collagenase (Collagenase Type I)<p> <b>Materials and Methods...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2021-06-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1351 |
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| Summary: | <b>Aim: </b>The aim of this study was to evaluate histopathologically the therapeutic
effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate)
injections in rabbits achill tendinopathies induced by collagenase (Collagenase
Type I)<p>
<b>Materials and Methods: </b>Achilles tendinopathy was formed with intrathendinous
injections of type I collagenase into the proximal and distal regions of
the right and left achilles tendons of 23 rabbits. PRP was injected distal to the
right Achilles tendons and MPA to the distal of the left Achilles tendons. A 0,9%
saline solution was also injected into the proximal parts of all achilles tendons.
Rabbits were euthanized 3, 6, and 8 weeks after the therapeutic injections. The
degree of histopathological degeneration of the tendons was made according
to the Modified Movin scoring.<p>
<b>Results:</b> Statistically significant differences were detected between the treatment
groups and the 0.9% saline injected group (p<0.05). In the histopathological
evaluations performed at the end of the 6th week no statistically
significant difference was detected between the treatment groups (p>0.05)
without tenocyte nuclei (p<0.05). At the end of the 8 weeks vascularization
and tenocyte nuclei (p<0.05) parameters was observed better in the Achilles
tendons of the rabbits undergoing PRP injection compared to rabbits with
MPA application.<p>
<b>Conclusion:</b> In conclusion, we consider that PRP injections tend to provide
an earlier improvement in the treatment of tendinopathy compared to MPA
injection. |
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| ISSN: | 1309-6958 2146-1953 |