Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort
Abstract Background With metabolic disorders on the rise globally, the cardiometabolic index (CMI) has emerged as a crucial predictor of mortality risks linked to cancer, cardiovascular disease, and diabetes. This novel index, which combines lipid metabolism and body composition, is the focus of thi...
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BMC
2024-12-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-024-02415-3 |
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| author | Junjie Wang Li Xiao Zhou Li |
| author_facet | Junjie Wang Li Xiao Zhou Li |
| author_sort | Junjie Wang |
| collection | DOAJ |
| description | Abstract Background With metabolic disorders on the rise globally, the cardiometabolic index (CMI) has emerged as a crucial predictor of mortality risks linked to cancer, cardiovascular disease, and diabetes. This novel index, which combines lipid metabolism and body composition, is the focus of this study, aimed at exploring its association with all-cause and specific mortality in an all-age adult population. Methods A longitudinal cohort study including 5,728 participants aged over 18 from nine cycles between 2001 and 2018 was enrolled and assessed. CMI served as the exposure variable, while outcomes included all-cause mortality and mortality due to cardiovascular disease, cancer, and diabetes. The Cox frailty model and average marginal effects were employed to evaluate the contribution of CMI to all-cause and specific mortality collectively. Restricted cubic spline analyses and stratified analyses were conducted to investigate potential nonlinear effects and interactions. Results The decreased participants exhibited considerably higher CMI than the alive’s. A positive association was found between CMI and all-cause mortality (HR=1.05, 95% CI=1.01-1.10). Notably, CMI was linked to an increased risk of cancer mortality (HR=1.02) and a reduced risk of cardiovascular disease mortality (HR=0.85). Furthermore, the average marginal effect of CMI on diabetes mortality was the largest (AME=0.499). The RCS curves revealed that participants had the lowest risk of all-cause mortality at a CMI of 0.618. Sensitivity analyses further supported these findings. Conclusion This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states. |
| format | Article |
| id | doaj-art-28f6655d428141cc9dc352be0809f6c5 |
| institution | DOAJ |
| issn | 1476-511X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-28f6655d428141cc9dc352be0809f6c52025-08-20T02:40:36ZengBMCLipids in Health and Disease1476-511X2024-12-0123111210.1186/s12944-024-02415-3Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohortJunjie Wang0Li Xiao1Zhou Li2Department of Geriatrics, First Affiliated Hospital, Army Medical UniversityDepartment of Geriatrics, First Affiliated Hospital, Army Medical UniversityDepartment of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University)Abstract Background With metabolic disorders on the rise globally, the cardiometabolic index (CMI) has emerged as a crucial predictor of mortality risks linked to cancer, cardiovascular disease, and diabetes. This novel index, which combines lipid metabolism and body composition, is the focus of this study, aimed at exploring its association with all-cause and specific mortality in an all-age adult population. Methods A longitudinal cohort study including 5,728 participants aged over 18 from nine cycles between 2001 and 2018 was enrolled and assessed. CMI served as the exposure variable, while outcomes included all-cause mortality and mortality due to cardiovascular disease, cancer, and diabetes. The Cox frailty model and average marginal effects were employed to evaluate the contribution of CMI to all-cause and specific mortality collectively. Restricted cubic spline analyses and stratified analyses were conducted to investigate potential nonlinear effects and interactions. Results The decreased participants exhibited considerably higher CMI than the alive’s. A positive association was found between CMI and all-cause mortality (HR=1.05, 95% CI=1.01-1.10). Notably, CMI was linked to an increased risk of cancer mortality (HR=1.02) and a reduced risk of cardiovascular disease mortality (HR=0.85). Furthermore, the average marginal effect of CMI on diabetes mortality was the largest (AME=0.499). The RCS curves revealed that participants had the lowest risk of all-cause mortality at a CMI of 0.618. Sensitivity analyses further supported these findings. Conclusion This study represents the first comprehensive assessment on the contribution of CMI to mortality across an all-age adult population, providing some insights for the comprehensive assessment of health and disease states.https://doi.org/10.1186/s12944-024-02415-3Cardiometabolic indexAll-cause and specific mortalityLongitudinal cohort studyCox Frailty modelAverage marginal effects |
| spellingShingle | Junjie Wang Li Xiao Zhou Li Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort Lipids in Health and Disease Cardiometabolic index All-cause and specific mortality Longitudinal cohort study Cox Frailty model Average marginal effects |
| title | Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort |
| title_full | Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort |
| title_fullStr | Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort |
| title_full_unstemmed | Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort |
| title_short | Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort |
| title_sort | cardiometabolic index and mortality risks elevated cancer and reduced cardiovascular mortality risk in a large cohort |
| topic | Cardiometabolic index All-cause and specific mortality Longitudinal cohort study Cox Frailty model Average marginal effects |
| url | https://doi.org/10.1186/s12944-024-02415-3 |
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