Animal models for enterovirus 71: Mechanisms, immunity, and applications
Enterovirus 71 (EV-A71) is a leading cause of hand, foot, and mouth disease (HFMD) in young children and is associated with a risk of severe neurological complications. Although inactivated vaccines ae available, their limited cross-protective efficacy and the lack of approved antiviral treatments h...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2523109 |
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| author | Zhenzhuang Zou Jiaying Liu Li Fu Yuexian He Guozhen Cui Bo Huang |
| author_facet | Zhenzhuang Zou Jiaying Liu Li Fu Yuexian He Guozhen Cui Bo Huang |
| author_sort | Zhenzhuang Zou |
| collection | DOAJ |
| description | Enterovirus 71 (EV-A71) is a leading cause of hand, foot, and mouth disease (HFMD) in young children and is associated with a risk of severe neurological complications. Although inactivated vaccines ae available, their limited cross-protective efficacy and the lack of approved antiviral treatments highlight the need for robust animal models to investigate viral pathogenesis and evaluate therapeutic interventions. This review provides a comprehensive overview of current EV-A71 animal models, particularly focusing on murine systems, and their applications in understanding disease mechanisms, supporting vaccine development, and developing antiviral strategies. The use of various EV-A71 strains, including clinical isolates, mouse-adapted strains, and infectious clones, in conjunction with rodent models such as BALB/c, ICR, and C57BL/6 neonatal mice, is examined. Additionally, transgenic, immunodeficient, and hybrid mouse models are also discussed for their ability to simulate key clinical features of infection, such as neurotropism, paralysis, and mortality. These models are indispensable for advancing therapeutic and vaccine research in pediatric infectious diseases. |
| format | Article |
| id | doaj-art-28f2bd0252ec472daf132acde1c1d0ed |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-28f2bd0252ec472daf132acde1c1d0ed2025-08-20T03:24:07ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2523109Animal models for enterovirus 71: Mechanisms, immunity, and applicationsZhenzhuang Zou0Jiaying Liu1Li Fu2Yuexian He3Guozhen Cui4Bo Huang5Department of Pediatrics, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, ChinaDepartment of Pediatrics, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, ChinaDepartment of Pediatrics, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, ChinaDepartment of Pediatrics, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, ChinaDepartment of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, ChinaDepartment of Pediatrics, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, Guangdong, ChinaEnterovirus 71 (EV-A71) is a leading cause of hand, foot, and mouth disease (HFMD) in young children and is associated with a risk of severe neurological complications. Although inactivated vaccines ae available, their limited cross-protective efficacy and the lack of approved antiviral treatments highlight the need for robust animal models to investigate viral pathogenesis and evaluate therapeutic interventions. This review provides a comprehensive overview of current EV-A71 animal models, particularly focusing on murine systems, and their applications in understanding disease mechanisms, supporting vaccine development, and developing antiviral strategies. The use of various EV-A71 strains, including clinical isolates, mouse-adapted strains, and infectious clones, in conjunction with rodent models such as BALB/c, ICR, and C57BL/6 neonatal mice, is examined. Additionally, transgenic, immunodeficient, and hybrid mouse models are also discussed for their ability to simulate key clinical features of infection, such as neurotropism, paralysis, and mortality. These models are indispensable for advancing therapeutic and vaccine research in pediatric infectious diseases.https://www.tandfonline.com/doi/10.1080/21645515.2025.2523109Enterovirus 71HFMDanimal modelstransgenic miceimmunodeficient models |
| spellingShingle | Zhenzhuang Zou Jiaying Liu Li Fu Yuexian He Guozhen Cui Bo Huang Animal models for enterovirus 71: Mechanisms, immunity, and applications Human Vaccines & Immunotherapeutics Enterovirus 71 HFMD animal models transgenic mice immunodeficient models |
| title | Animal models for enterovirus 71: Mechanisms, immunity, and applications |
| title_full | Animal models for enterovirus 71: Mechanisms, immunity, and applications |
| title_fullStr | Animal models for enterovirus 71: Mechanisms, immunity, and applications |
| title_full_unstemmed | Animal models for enterovirus 71: Mechanisms, immunity, and applications |
| title_short | Animal models for enterovirus 71: Mechanisms, immunity, and applications |
| title_sort | animal models for enterovirus 71 mechanisms immunity and applications |
| topic | Enterovirus 71 HFMD animal models transgenic mice immunodeficient models |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2523109 |
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