C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010
Abstract Background Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP. Methods Participants from NHANES 2001–2010 were enrolled. CMI wa...
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BMC
2025-07-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-025-02603-9 |
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| author | Yike Wang Zeyu Liu Haoyu Wu Chunsheng Wang |
| author_facet | Yike Wang Zeyu Liu Haoyu Wu Chunsheng Wang |
| author_sort | Yike Wang |
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| description | Abstract Background Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP. Methods Participants from NHANES 2001–2010 were enrolled. CMI was computed based on anthropometric and biochemical indexes, covering height, waist circumference, triglyceride, and high-density lipoprotein cholesterol. OA diagnosis data were derived from the Medical Conditions questionnaires. Multivariate logistic regressions, restricted cubic spline (RCS) analysis, subgroup analyses, and interaction tests were implemented to investigate the association. A mediation analysis was employed to verify the mediating role of CRP. Results After controlling for all covariates, CMI was significantly linked with OA (OR: 1.07, 95% CI (1.01, 1.13), P = 0.038). RCS analyses elicited a non-linear link between CMI and OA (P − non − linear = 0.0012). The inflection point was 0.54. Threshold effect analysis was conducted through two-segment linear regression, including the left side ( < = 0.54) (OR: 2.06, 95% CI: 1.03, 6.58) and the right side of the inflection point (> 0.54) (OR: 0.40, 95% CI: 0.15, 1.03). CRP partially mediated the link between CMI and OA, around 7.59% of the total effect. Conclusion CMI is positively linked with OA, with CRP mediating the link. This paper unveils novel perspectives on the mechanism that links CMI to OA. Managing CMI and monitoring CRP levels may alleviate OA. |
| format | Article |
| id | doaj-art-28f0bd8c118d4f3e96e79ec4ee81153a |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | Lipids in Health and Disease |
| spelling | doaj-art-28f0bd8c118d4f3e96e79ec4ee81153a2025-08-20T03:46:29ZengBMCLipids in Health and Disease1476-511X2025-07-012411910.1186/s12944-025-02603-9C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010Yike Wang0Zeyu Liu1Haoyu Wu2Chunsheng Wang3Departments of Bone and Joint Surgery, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartments of Bone and Joint Surgery, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartments of Bone and Joint Surgery, The Second Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Background Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP. Methods Participants from NHANES 2001–2010 were enrolled. CMI was computed based on anthropometric and biochemical indexes, covering height, waist circumference, triglyceride, and high-density lipoprotein cholesterol. OA diagnosis data were derived from the Medical Conditions questionnaires. Multivariate logistic regressions, restricted cubic spline (RCS) analysis, subgroup analyses, and interaction tests were implemented to investigate the association. A mediation analysis was employed to verify the mediating role of CRP. Results After controlling for all covariates, CMI was significantly linked with OA (OR: 1.07, 95% CI (1.01, 1.13), P = 0.038). RCS analyses elicited a non-linear link between CMI and OA (P − non − linear = 0.0012). The inflection point was 0.54. Threshold effect analysis was conducted through two-segment linear regression, including the left side ( < = 0.54) (OR: 2.06, 95% CI: 1.03, 6.58) and the right side of the inflection point (> 0.54) (OR: 0.40, 95% CI: 0.15, 1.03). CRP partially mediated the link between CMI and OA, around 7.59% of the total effect. Conclusion CMI is positively linked with OA, with CRP mediating the link. This paper unveils novel perspectives on the mechanism that links CMI to OA. Managing CMI and monitoring CRP levels may alleviate OA.https://doi.org/10.1186/s12944-025-02603-9Cardiometabolic indexOsteoarthritisNational health and nutrition examination surveyC-reactive protein |
| spellingShingle | Yike Wang Zeyu Liu Haoyu Wu Chunsheng Wang C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010 Lipids in Health and Disease Cardiometabolic index Osteoarthritis National health and nutrition examination survey C-reactive protein |
| title | C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010 |
| title_full | C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010 |
| title_fullStr | C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010 |
| title_full_unstemmed | C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010 |
| title_short | C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001–2010 |
| title_sort | c reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis insights from nhanes 2001 2010 |
| topic | Cardiometabolic index Osteoarthritis National health and nutrition examination survey C-reactive protein |
| url | https://doi.org/10.1186/s12944-025-02603-9 |
| work_keys_str_mv | AT yikewang creactiveproteinasamediatorinthelinkbetweencardiometabolicindexandosteoarthritisinsightsfromnhanes20012010 AT zeyuliu creactiveproteinasamediatorinthelinkbetweencardiometabolicindexandosteoarthritisinsightsfromnhanes20012010 AT haoyuwu creactiveproteinasamediatorinthelinkbetweencardiometabolicindexandosteoarthritisinsightsfromnhanes20012010 AT chunshengwang creactiveproteinasamediatorinthelinkbetweencardiometabolicindexandosteoarthritisinsightsfromnhanes20012010 |