Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis
Abstract Background Fibrinogen albumin ratio (FAR) is recently considered as a new marker for inflammation. This study aimed to evaluate the value of FAR as a predictor biomarker of ankylosing spondylitis (AS) disease activity as well as its correlation with the spondyloarthritis research consortium...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-07-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-025-01518-w |
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| author | Mennatallah Mohammed Mohammed Mustafa Hala Abdulhady Saleh Mahmoud Mohamed Fathallah Osama Hassan Bakheet Mohamed Abobakr El Seddik Mona Mohamed El Bably |
| author_facet | Mennatallah Mohammed Mohammed Mustafa Hala Abdulhady Saleh Mahmoud Mohamed Fathallah Osama Hassan Bakheet Mohamed Abobakr El Seddik Mona Mohamed El Bably |
| author_sort | Mennatallah Mohammed Mohammed Mustafa |
| collection | DOAJ |
| description | Abstract Background Fibrinogen albumin ratio (FAR) is recently considered as a new marker for inflammation. This study aimed to evaluate the value of FAR as a predictor biomarker of ankylosing spondylitis (AS) disease activity as well as its correlation with the spondyloarthritis research consortium of Canada MRI index (SPARCC) of sacroiliac joints (SIJs) in detection of disease activity in AS. The study included 25 adult AS patients and 10 healthy controls who were matched for age and sex. Based on disease activity, patients were divided into two groups: Group (I) consisted of 15 patients with active disease with a BASDAI ≥ 4, and group (II) consisted of 10 patients with inactive disease with a BASDAI < 4. Results The mean of patients age was (35.2 years); patient’s disease duration range (1.5–18 years). AS patients with disease activity had a higher FAR and SPARCC MRI index in comparison with the remission and control groups (P < 0.01). FAR and the SPARCC MRI index were found to be positively correlated in patients with active illness (P < 0.01). Cut-off value of FAR > 0.086, SPARCC index > 4. FAR and SPARCC MRI index can significantly differentiate between active and inactive group (P < 0.001) with 100% sensitivity and specificity. FAR can significantly differentiate between AS patients and health controls (P < 0.001), with 80% sensitivity and 100% specificity. SPARCC index also can significantly differentiate between AS patients and health controls (P < 0.001) but with 88% sensitivity and 100% specificity. Conclusions The study concluded that FAR and SPARCC MRI index were elevated in patients with active AS disease. FAR and SPARCC MRI index can serve as a new parameter in monitoring activity in ankylosing spondylitis disease. |
| format | Article |
| id | doaj-art-28e9d1f86a5e4d908eb5e43f397d43ac |
| institution | Kabale University |
| issn | 2090-4762 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj-art-28e9d1f86a5e4d908eb5e43f397d43ac2025-08-20T04:01:53ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622025-07-0156111910.1186/s43055-025-01518-wFibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitisMennatallah Mohammed Mohammed Mustafa0Hala Abdulhady Saleh1Mahmoud Mohamed Fathallah2Osama Hassan Bakheet3Mohamed Abobakr El Seddik4Mona Mohamed El Bably5Ministry of Public HealthAin Shams UniversityAin Shams UniversityArmed Forces College of MedicineArmed Forces College of MedicineAin Shams UniversityAbstract Background Fibrinogen albumin ratio (FAR) is recently considered as a new marker for inflammation. This study aimed to evaluate the value of FAR as a predictor biomarker of ankylosing spondylitis (AS) disease activity as well as its correlation with the spondyloarthritis research consortium of Canada MRI index (SPARCC) of sacroiliac joints (SIJs) in detection of disease activity in AS. The study included 25 adult AS patients and 10 healthy controls who were matched for age and sex. Based on disease activity, patients were divided into two groups: Group (I) consisted of 15 patients with active disease with a BASDAI ≥ 4, and group (II) consisted of 10 patients with inactive disease with a BASDAI < 4. Results The mean of patients age was (35.2 years); patient’s disease duration range (1.5–18 years). AS patients with disease activity had a higher FAR and SPARCC MRI index in comparison with the remission and control groups (P < 0.01). FAR and the SPARCC MRI index were found to be positively correlated in patients with active illness (P < 0.01). Cut-off value of FAR > 0.086, SPARCC index > 4. FAR and SPARCC MRI index can significantly differentiate between active and inactive group (P < 0.001) with 100% sensitivity and specificity. FAR can significantly differentiate between AS patients and health controls (P < 0.001), with 80% sensitivity and 100% specificity. SPARCC index also can significantly differentiate between AS patients and health controls (P < 0.001) but with 88% sensitivity and 100% specificity. Conclusions The study concluded that FAR and SPARCC MRI index were elevated in patients with active AS disease. FAR and SPARCC MRI index can serve as a new parameter in monitoring activity in ankylosing spondylitis disease.https://doi.org/10.1186/s43055-025-01518-wSpondylitisAnkylosingSacroiliac jointFibrinogenMagnetic resonance imagingAlbumins |
| spellingShingle | Mennatallah Mohammed Mohammed Mustafa Hala Abdulhady Saleh Mahmoud Mohamed Fathallah Osama Hassan Bakheet Mohamed Abobakr El Seddik Mona Mohamed El Bably Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis The Egyptian Journal of Radiology and Nuclear Medicine Spondylitis Ankylosing Sacroiliac joint Fibrinogen Magnetic resonance imaging Albumins |
| title | Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis |
| title_full | Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis |
| title_fullStr | Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis |
| title_full_unstemmed | Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis |
| title_short | Fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis |
| title_sort | fibrinogen albumin ratio as a predictor marker of disease activity in ankylosing spondylitis |
| topic | Spondylitis Ankylosing Sacroiliac joint Fibrinogen Magnetic resonance imaging Albumins |
| url | https://doi.org/10.1186/s43055-025-01518-w |
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