Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study
Abstract Thrombocytopenia is a common hematologic concern in neonates and can lead to severe complications, including significant bleeding particularly intracranial hemorrhage. This risk is especially critical in preterm infants or those with other coexisting conditions. While neonatal thrombocytope...
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Nature Portfolio
2025-04-01
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| author | Asnake Tadesse Abate Gezahagn Demsu Gedefaw Chanyalew Worku Kassahun Mengistu Mekonnen Kelkay |
| author_facet | Asnake Tadesse Abate Gezahagn Demsu Gedefaw Chanyalew Worku Kassahun Mengistu Mekonnen Kelkay |
| author_sort | Asnake Tadesse Abate |
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| description | Abstract Thrombocytopenia is a common hematologic concern in neonates and can lead to severe complications, including significant bleeding particularly intracranial hemorrhage. This risk is especially critical in preterm infants or those with other coexisting conditions. While neonatal thrombocytopenia has been studied in some countries, there is limited data and understanding about its prevalence, and associated factors in resource-limited countries especially in Ethiopia. So this study aimed to assess the prevalence and factors associated with thrombocytopenia among neonates admitted to the neonatal intensive care unit of Northwest Amhara Region Comprehensive Specialized Hospitals in Northwest Ethiopia, 2022. Institution-based cross-sectional study design was conducted from October 05 to November 03, 2022, and a systematic random sampling technique was used to select 423 study participants. Data were collected by interviewing mothers and reviewing neonates’ medical records. Data were entered into Epi-Data version 4.6.0 and exported to STATA version 14 for analysis. Both bivariable and multivariable logistic regression models were used for analysis. P-value of less than 0.05 and odds ratio with 95% CI was used to declare the presence of association. A total of 415 neonate-mother pairs were involved with a response rate of 98.1%. The prevalence of thrombocytopenia among neonates admitted to the neonatal intensive care unit Is found to be 26.02%; [95% CI (22.01–30.48%)]. In the multivariable analysis severe pre-eclampsia (AOR = 2.84 95% CI 1.29–6.27), prolonged rupture of membrane (AOR = 2.85 95% CI 1.21–6.72), neonatal sepsis (AOR = 6.50 95% CI 3.58–11.79), perinatal asphyxia (AOR = 4.15 95% CI 1.97–8.76), and necrotizing enterocolitis (AOR = 3.71 95% CI 1.68–8.19) were significant factors to thrombocytopenia. To decrease the occurrence of neonatal thrombocytopenia better to give special attention and priority to neonates diagnosed with sepsis, perinatal asphyxia, necrotizing enterocolitis, and mothers who had prolonged rupture of membrane or severe pre-eclampsia. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-28e441f0506f4452b223becfb66e64e72025-08-20T02:11:46ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-93042-0Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional studyAsnake Tadesse Abate0Gezahagn Demsu Gedefaw1Chanyalew Worku Kassahun2Mengistu Mekonnen Kelkay3Department of Neonatal Health Nursing, School of Nursing, College of Medicine and Health Sciences, and Specialized Hospital, University of GondarDepartment of Neonatal Health Nursing, School of Nursing, College of Medicine and Health Sciences, and Specialized Hospital, University of GondarDepartment of Medical Nursing, School of Nursing, University of GondarDepartment of Pediatrics and Child Health Nursing, School of Nursing, University of GondarAbstract Thrombocytopenia is a common hematologic concern in neonates and can lead to severe complications, including significant bleeding particularly intracranial hemorrhage. This risk is especially critical in preterm infants or those with other coexisting conditions. While neonatal thrombocytopenia has been studied in some countries, there is limited data and understanding about its prevalence, and associated factors in resource-limited countries especially in Ethiopia. So this study aimed to assess the prevalence and factors associated with thrombocytopenia among neonates admitted to the neonatal intensive care unit of Northwest Amhara Region Comprehensive Specialized Hospitals in Northwest Ethiopia, 2022. Institution-based cross-sectional study design was conducted from October 05 to November 03, 2022, and a systematic random sampling technique was used to select 423 study participants. Data were collected by interviewing mothers and reviewing neonates’ medical records. Data were entered into Epi-Data version 4.6.0 and exported to STATA version 14 for analysis. Both bivariable and multivariable logistic regression models were used for analysis. P-value of less than 0.05 and odds ratio with 95% CI was used to declare the presence of association. A total of 415 neonate-mother pairs were involved with a response rate of 98.1%. The prevalence of thrombocytopenia among neonates admitted to the neonatal intensive care unit Is found to be 26.02%; [95% CI (22.01–30.48%)]. In the multivariable analysis severe pre-eclampsia (AOR = 2.84 95% CI 1.29–6.27), prolonged rupture of membrane (AOR = 2.85 95% CI 1.21–6.72), neonatal sepsis (AOR = 6.50 95% CI 3.58–11.79), perinatal asphyxia (AOR = 4.15 95% CI 1.97–8.76), and necrotizing enterocolitis (AOR = 3.71 95% CI 1.68–8.19) were significant factors to thrombocytopenia. To decrease the occurrence of neonatal thrombocytopenia better to give special attention and priority to neonates diagnosed with sepsis, perinatal asphyxia, necrotizing enterocolitis, and mothers who had prolonged rupture of membrane or severe pre-eclampsia.https://doi.org/10.1038/s41598-025-93042-0NeonateThrombocytopeniaHospitalsNorthwest AmharaEthiopia |
| spellingShingle | Asnake Tadesse Abate Gezahagn Demsu Gedefaw Chanyalew Worku Kassahun Mengistu Mekonnen Kelkay Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study Scientific Reports Neonate Thrombocytopenia Hospitals Northwest Amhara Ethiopia |
| title | Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study |
| title_full | Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study |
| title_fullStr | Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study |
| title_full_unstemmed | Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study |
| title_short | Prevalence and associated factors of thrombocytopenia among neonates in Northwest Amhara region comprehensive specialized hospitals, Ethiopia: a cross sectional study |
| title_sort | prevalence and associated factors of thrombocytopenia among neonates in northwest amhara region comprehensive specialized hospitals ethiopia a cross sectional study |
| topic | Neonate Thrombocytopenia Hospitals Northwest Amhara Ethiopia |
| url | https://doi.org/10.1038/s41598-025-93042-0 |
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