The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives
Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2014-08-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/26165/23623 |
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| author | I. M. Bilay E. O. Mihayluk V. V. Parchenko A. G. Kaplaushenko A. I. Panasenko E. G. Knysh |
| author_facet | I. M. Bilay E. O. Mihayluk V. V. Parchenko A. G. Kaplaushenko A. I. Panasenko E. G. Knysh |
| author_sort | I. M. Bilay |
| collection | DOAJ |
| description | Aim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats.
Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment.
Сonclusion. Screening has shown that these class of compounds is promising for further research. |
| format | Article |
| id | doaj-art-28dcf5e34b23460e853089e5d92b33e8 |
| institution | DOAJ |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-28dcf5e34b23460e853089e5d92b33e82025-08-20T02:41:58ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322014-08-012575910.14739/2409-2932.2014.2.26165The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivativesI. M. BilayE. O. MihaylukV. V. ParchenkoA. G. KaplaushenkoA. I. PanasenkoE. G. KnyshAim. The search of new high-effective drugs is an actual problem of modern science. The purpose of our research was the pharmacological screening of 1,2,4-triazoles derivatives. Experiments have been performed on adult Wistar white rats. Methods and results. Compounds have been entered in a 1/10 dose of LD50, which have been determined before performing experiments. The article presents hepatoprotective activity of new synthesized compounds in simulated acute liver injury. We present a comparison with reference drugs in the experiment. Сonclusion. Screening has shown that these class of compounds is promising for further research.http://pharmed.zsmu.edu.ua/article/view/26165/23623Pharmacological ActionsDrug ScreeningAnimal ExperimentalToxic Hepatitis14-triazole |
| spellingShingle | I. M. Bilay E. O. Mihayluk V. V. Parchenko A. G. Kaplaushenko A. I. Panasenko E. G. Knysh The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Pharmacological Actions Drug Screening Animal Experimental Toxic Hepatitis 1 4-triazole |
| title | The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives |
| title_full | The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives |
| title_fullStr | The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives |
| title_full_unstemmed | The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives |
| title_short | The research of hepatoprotective activity in experimental hepatitis influenced by 1,2,4-triazole derivatives |
| title_sort | research of hepatoprotective activity in experimental hepatitis influenced by 1 2 4 triazole derivatives |
| topic | Pharmacological Actions Drug Screening Animal Experimental Toxic Hepatitis 1 4-triazole |
| url | http://pharmed.zsmu.edu.ua/article/view/26165/23623 |
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