Targeting GATA transcription factors – a novel strategy for anti-aging interventions?
GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2019-05-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2019a-zimmermann-microbial-cell/ |
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| author | Andreas Zimmermann Katharina Kainz Sebastian J. Hofer Maria A. Bauer Sabrina Schroeder Jörn Dengjel Federico Pietrocola Oliver Kepp Christoph Ruckenstuhl Tobias Eisenberg Stephan J. Sigrist Frank Madeo Guido Kroemer Didac Carmona-Gutierrez |
| author_facet | Andreas Zimmermann Katharina Kainz Sebastian J. Hofer Maria A. Bauer Sabrina Schroeder Jörn Dengjel Federico Pietrocola Oliver Kepp Christoph Ruckenstuhl Tobias Eisenberg Stephan J. Sigrist Frank Madeo Guido Kroemer Didac Carmona-Gutierrez |
| author_sort | Andreas Zimmermann |
| collection | DOAJ |
| description | GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC), that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged lifespan by DMC treatment depends on autophagy, a protective cellular self-cleansing mechanism. In yeast, DMC reduces the activity of the GATA TF Gln3 and, genetic deletion of Gln3 is sufficient to increase autophagy levels during cellular aging. In addition, we observed similar changes in the abundance of several amino acids in the metabolome of DMC-treated and GATA/Gln3 depleted cells. Here, we examine current data on the involvement of GATA TFs in the regulation of autophagy and longevity in different organisms and explore if GATA TFs might be suitable targets for anti-aging interventions. |
| format | Article |
| id | doaj-art-28d7ebac62694e2da572829c63d9e796 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-28d7ebac62694e2da572829c63d9e7962025-08-20T02:57:37ZengShared Science Publishers OGMicrobial Cell2311-26382019-05-016521221610.15698/mic2019.05.676Targeting GATA transcription factors – a novel strategy for anti-aging interventions?Andreas Zimmermann0Katharina Kainz1Sebastian J. Hofer2Maria A. Bauer3Sabrina Schroeder4Jörn Dengjel5Federico Pietrocola6Oliver Kepp7Christoph Ruckenstuhl8Tobias Eisenberg9Stephan J. Sigrist10Frank Madeo11Guido Kroemer12Didac Carmona-Gutierrez13Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Department of Biology, Université de Fribourg, Switzerland.Institute for Research in Biomedicine; Barcelona, Spain.Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers , INSERM U 1138, Paris, France.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers , INSERM U 1138, Paris, France.Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC), that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged lifespan by DMC treatment depends on autophagy, a protective cellular self-cleansing mechanism. In yeast, DMC reduces the activity of the GATA TF Gln3 and, genetic deletion of Gln3 is sufficient to increase autophagy levels during cellular aging. In addition, we observed similar changes in the abundance of several amino acids in the metabolome of DMC-treated and GATA/Gln3 depleted cells. Here, we examine current data on the involvement of GATA TFs in the regulation of autophagy and longevity in different organisms and explore if GATA TFs might be suitable targets for anti-aging interventions.http://microbialcell.com/researcharticles/2019a-zimmermann-microbial-cell/GATAyeastanti-agingflavonoidsamino acidsautophagy |
| spellingShingle | Andreas Zimmermann Katharina Kainz Sebastian J. Hofer Maria A. Bauer Sabrina Schroeder Jörn Dengjel Federico Pietrocola Oliver Kepp Christoph Ruckenstuhl Tobias Eisenberg Stephan J. Sigrist Frank Madeo Guido Kroemer Didac Carmona-Gutierrez Targeting GATA transcription factors – a novel strategy for anti-aging interventions? Microbial Cell GATA yeast anti-aging flavonoids amino acids autophagy |
| title | Targeting GATA transcription factors – a novel strategy for anti-aging interventions? |
| title_full | Targeting GATA transcription factors – a novel strategy for anti-aging interventions? |
| title_fullStr | Targeting GATA transcription factors – a novel strategy for anti-aging interventions? |
| title_full_unstemmed | Targeting GATA transcription factors – a novel strategy for anti-aging interventions? |
| title_short | Targeting GATA transcription factors – a novel strategy for anti-aging interventions? |
| title_sort | targeting gata transcription factors a novel strategy for anti aging interventions |
| topic | GATA yeast anti-aging flavonoids amino acids autophagy |
| url | http://microbialcell.com/researcharticles/2019a-zimmermann-microbial-cell/ |
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