BRD4 as the key lactylation related gene in heart failure identified through bioinformatics analysis

BRD4 as the key lactylation related gene in heart failure identified through bioinformatics analysis

Abstract Lactylation modification is postulated to influence the progression of heart failure (HF) through diverse pathways, albeit the underlying mechanisms remain elusive. Methods In this study, bioinformatics approaches were employed to analyze the HF dataset (GSE5406) retrieved from the Gene Exp...

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Bibliographic Details
Main Authors: Kaiyuan Li, Lingyu Han, Xiaowen Wang, Zhipeng Zheng, Min Sha, Jun Ye, Li Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Heart failure
Lactylation
LASSO
WGCNA
BRD4
Online Access:https://doi.org/10.1038/s41598-025-91506-x
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