Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial
Introduction Postoperative pulmonary complications (PPCs) are the most common complications following thoracoscopic surgery, resulting in increased hospital costs and perioperative mortality. Studies have shown that intravenous lidocaine infusion can exert its anti-inflammatory properties by reducin...
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e066828.full |
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| author | Li Liu Fei Wang Yanxia He Miyi Zhou Qingyong Luo Zuojia Zeng Si Zeng Qian Lei |
| author_facet | Li Liu Fei Wang Yanxia He Miyi Zhou Qingyong Luo Zuojia Zeng Si Zeng Qian Lei |
| author_sort | Li Liu |
| collection | DOAJ |
| description | Introduction Postoperative pulmonary complications (PPCs) are the most common complications following thoracoscopic surgery, resulting in increased hospital costs and perioperative mortality. Studies have shown that intravenous lidocaine infusion can exert its anti-inflammatory properties by reducing the release of proinflammatory cytokines. This study is designed to investigate whether intraoperative intravenous lidocaine infusion can reduce the incidence of PPCs in adult patients undergoing video-assisted thoracoscopic lung resection surgery.Methods and analysis This single-centre, double-blinded study will enrol 366 patients scheduled for video-assisted thoracoscopic lung resection surgery. Patients will be randomly assigned to the lidocaine or placebo infusion group in a 1: 1 ratio. The lidocaine group will receive lidocaine intravenously during the intraoperative period, while the placebo group will be administered normal saline at an equal volume, infusion rate and timing. The primary outcome is the incidence of PPCs within 7 days following surgery. The secondary outcomes are quality of postoperative recovery 40 scores; length of hospital stay (determined by the number of days from admission to discharge); incidence of moderate to severe pain within 24 and 48 hours at rest and when coughing; incidence of additional rescue analgesics use and incidence of adverse events.Ethics and dissemination The study was reviewed and approved by the Ethics Committee of Sichuan Provincial People’s Hospital (approval no. 20222241). Written informed consent will be obtained from all patients before randomisation. The results of this trial will be disseminated in a peer-reviewed journal.Trial registration number ChiCTR2200061979. |
| format | Article |
| id | doaj-art-28d3a100b9634e1a9cc4e4622d795206 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-28d3a100b9634e1a9cc4e4622d7952062025-08-20T02:14:50ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-066828Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trialLi Liu0Fei Wang1Yanxia He2Miyi Zhou3Qingyong Luo4Zuojia Zeng5Si Zeng6Qian Lei71 Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China8 Department of Mental Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan People`s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaIntroduction Postoperative pulmonary complications (PPCs) are the most common complications following thoracoscopic surgery, resulting in increased hospital costs and perioperative mortality. Studies have shown that intravenous lidocaine infusion can exert its anti-inflammatory properties by reducing the release of proinflammatory cytokines. This study is designed to investigate whether intraoperative intravenous lidocaine infusion can reduce the incidence of PPCs in adult patients undergoing video-assisted thoracoscopic lung resection surgery.Methods and analysis This single-centre, double-blinded study will enrol 366 patients scheduled for video-assisted thoracoscopic lung resection surgery. Patients will be randomly assigned to the lidocaine or placebo infusion group in a 1: 1 ratio. The lidocaine group will receive lidocaine intravenously during the intraoperative period, while the placebo group will be administered normal saline at an equal volume, infusion rate and timing. The primary outcome is the incidence of PPCs within 7 days following surgery. The secondary outcomes are quality of postoperative recovery 40 scores; length of hospital stay (determined by the number of days from admission to discharge); incidence of moderate to severe pain within 24 and 48 hours at rest and when coughing; incidence of additional rescue analgesics use and incidence of adverse events.Ethics and dissemination The study was reviewed and approved by the Ethics Committee of Sichuan Provincial People’s Hospital (approval no. 20222241). Written informed consent will be obtained from all patients before randomisation. The results of this trial will be disseminated in a peer-reviewed journal.Trial registration number ChiCTR2200061979.https://bmjopen.bmj.com/content/12/12/e066828.full |
| spellingShingle | Li Liu Fei Wang Yanxia He Miyi Zhou Qingyong Luo Zuojia Zeng Si Zeng Qian Lei Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial BMJ Open |
| title | Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial |
| title_full | Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial |
| title_fullStr | Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial |
| title_full_unstemmed | Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial |
| title_short | Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial |
| title_sort | efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video assisted thoracoscopic lung resection surgery protocol for a randomised controlled trial |
| url | https://bmjopen.bmj.com/content/12/12/e066828.full |
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