Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study
Abstract Parkinson’s disease with mild cognitive impairment (PD-MCI) includes various cognitive deficits, classified into two subtypes based on the “dual syndrome hypothesis”: the executive-dominant dopamine pathway dysfunction impairing executive and language functions (PD-EL subtype), and the visu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01013-z |
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| author | Hai-Yang Wang Lu Ren Zhongrui Yan Tingting Zhou Zhanhua Liang |
| author_facet | Hai-Yang Wang Lu Ren Zhongrui Yan Tingting Zhou Zhanhua Liang |
| author_sort | Hai-Yang Wang |
| collection | DOAJ |
| description | Abstract Parkinson’s disease with mild cognitive impairment (PD-MCI) includes various cognitive deficits, classified into two subtypes based on the “dual syndrome hypothesis”: the executive-dominant dopamine pathway dysfunction impairing executive and language functions (PD-EL subtype), and the visuospatial-dominant non-dopaminergic dysfunction affecting visuospatial perception, attention, and memory (PD-VAM subtype). This study involved 182 participants (122 PD, 60 controls) undergoing cognitive assessments. Using PD-MCI Level II criteria, patients were categorized as PD with normal cognition (PD-NC, 48), PD-EL (34), or PD-VAM (40). Functional near-infrared spectroscopy measured brain activation during verbal fluency (executive) and line orientation (visuospatial) tasks. PD-EL showed lower word accuracy and reduced activation in dorsolateral/ventrolateral prefrontal cortices, supplementary motor area, and orbitofrontal cortex compared to PD-NC. PD-VAM had lower line orientation scores and reduced ventrolateral prefrontal activation. These findings suggest that PD-MCI subtypes may exhibit differential neural activation patterns reflecting their cognitive deficits, underscoring the need for targeted interventions and mechanistic research. |
| format | Article |
| id | doaj-art-28d2823470134f4a89695e40cbadcb74 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-28d2823470134f4a89695e40cbadcb742025-08-20T03:21:02ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-0111111010.1038/s41531-025-01013-zNeural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS studyHai-Yang Wang0Lu Ren1Zhongrui Yan2Tingting Zhou3Zhanhua Liang4Department of Neurology, The First Affiliated Hospital of Dalian Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Dalian Medical UniversityDepartment of Neurology, Jining No. 1 People’s Hospital, Shandong First Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Dalian Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Dalian Medical UniversityAbstract Parkinson’s disease with mild cognitive impairment (PD-MCI) includes various cognitive deficits, classified into two subtypes based on the “dual syndrome hypothesis”: the executive-dominant dopamine pathway dysfunction impairing executive and language functions (PD-EL subtype), and the visuospatial-dominant non-dopaminergic dysfunction affecting visuospatial perception, attention, and memory (PD-VAM subtype). This study involved 182 participants (122 PD, 60 controls) undergoing cognitive assessments. Using PD-MCI Level II criteria, patients were categorized as PD with normal cognition (PD-NC, 48), PD-EL (34), or PD-VAM (40). Functional near-infrared spectroscopy measured brain activation during verbal fluency (executive) and line orientation (visuospatial) tasks. PD-EL showed lower word accuracy and reduced activation in dorsolateral/ventrolateral prefrontal cortices, supplementary motor area, and orbitofrontal cortex compared to PD-NC. PD-VAM had lower line orientation scores and reduced ventrolateral prefrontal activation. These findings suggest that PD-MCI subtypes may exhibit differential neural activation patterns reflecting their cognitive deficits, underscoring the need for targeted interventions and mechanistic research.https://doi.org/10.1038/s41531-025-01013-z |
| spellingShingle | Hai-Yang Wang Lu Ren Zhongrui Yan Tingting Zhou Zhanhua Liang Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study npj Parkinson's Disease |
| title | Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study |
| title_full | Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study |
| title_fullStr | Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study |
| title_full_unstemmed | Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study |
| title_short | Neural basis of dysexecutive and visuospatial impairments in Parkinson’s disease with MCI: a task-based fNIRS study |
| title_sort | neural basis of dysexecutive and visuospatial impairments in parkinson s disease with mci a task based fnirs study |
| url | https://doi.org/10.1038/s41531-025-01013-z |
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