Current advances and challenges in mpox vaccine development: a global landscape

Given the surge in mpox outbreaks in 2022 and the advancements in domestic and international vaccine research, the effectiveness of smallpox vaccines in providing cross-protection against mpox remains crucial. Having learned from the COVID-19 pandemic, it is significant to continue evaluating existi...

Full description

Saved in:
Bibliographic Details
Main Authors: Maryam Shafaati, Shayan Forghani, Amirhossein Shahsavand Davoudi, Reza Samiee, Keyhan Mohammadi, Samaneh Akbarpour, Arash Seifi, Mohammadreza Salehi, Maryam Zare
Format: Article
Language:English
Published: SAGE Publishing 2025-01-01
Series:Therapeutic Advances in Vaccines and Immunotherapy
Online Access:https://doi.org/10.1177/25151355251314339
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832584162358329344
author Maryam Shafaati
Shayan Forghani
Amirhossein Shahsavand Davoudi
Reza Samiee
Keyhan Mohammadi
Samaneh Akbarpour
Arash Seifi
Mohammadreza Salehi
Maryam Zare
author_facet Maryam Shafaati
Shayan Forghani
Amirhossein Shahsavand Davoudi
Reza Samiee
Keyhan Mohammadi
Samaneh Akbarpour
Arash Seifi
Mohammadreza Salehi
Maryam Zare
author_sort Maryam Shafaati
collection DOAJ
description Given the surge in mpox outbreaks in 2022 and the advancements in domestic and international vaccine research, the effectiveness of smallpox vaccines in providing cross-protection against mpox remains crucial. Having learned from the COVID-19 pandemic, it is significant to continue evaluating existing vaccines to ensure their safety and efficacy. Developing new vaccines for widespread use against mpox and its emerging strains also serves as a preventive strategy in the ongoing battle against this dynamic infection. Here’s an opportunity to control human-to-human transmission, give short deadlines, and avoid vaccine disparity. Public health systems must take decisive action to prevent the global spread of mpox, particularly among vulnerable groups. This action should include strengthening global surveillance, improving vaccine access, and ensuring equitable distribution, particularly in resource-poor settings, to prevent future outbreaks. This review aims to assess recent advancements and barriers in mpox vaccine development, emphasizing cross-protection and equitable vaccine distribution in resource-poor settings.
format Article
id doaj-art-28d22a126c7d4c8a9d15968c42914d4b
institution Kabale University
issn 2515-1363
language English
publishDate 2025-01-01
publisher SAGE Publishing
record_format Article
series Therapeutic Advances in Vaccines and Immunotherapy
spelling doaj-art-28d22a126c7d4c8a9d15968c42914d4b2025-01-27T15:04:01ZengSAGE PublishingTherapeutic Advances in Vaccines and Immunotherapy2515-13632025-01-011310.1177/25151355251314339Current advances and challenges in mpox vaccine development: a global landscapeMaryam ShafaatiShayan ForghaniAmirhossein Shahsavand DavoudiReza SamieeKeyhan MohammadiSamaneh AkbarpourArash SeifiMohammadreza SalehiMaryam ZareGiven the surge in mpox outbreaks in 2022 and the advancements in domestic and international vaccine research, the effectiveness of smallpox vaccines in providing cross-protection against mpox remains crucial. Having learned from the COVID-19 pandemic, it is significant to continue evaluating existing vaccines to ensure their safety and efficacy. Developing new vaccines for widespread use against mpox and its emerging strains also serves as a preventive strategy in the ongoing battle against this dynamic infection. Here’s an opportunity to control human-to-human transmission, give short deadlines, and avoid vaccine disparity. Public health systems must take decisive action to prevent the global spread of mpox, particularly among vulnerable groups. This action should include strengthening global surveillance, improving vaccine access, and ensuring equitable distribution, particularly in resource-poor settings, to prevent future outbreaks. This review aims to assess recent advancements and barriers in mpox vaccine development, emphasizing cross-protection and equitable vaccine distribution in resource-poor settings.https://doi.org/10.1177/25151355251314339
spellingShingle Maryam Shafaati
Shayan Forghani
Amirhossein Shahsavand Davoudi
Reza Samiee
Keyhan Mohammadi
Samaneh Akbarpour
Arash Seifi
Mohammadreza Salehi
Maryam Zare
Current advances and challenges in mpox vaccine development: a global landscape
Therapeutic Advances in Vaccines and Immunotherapy
title Current advances and challenges in mpox vaccine development: a global landscape
title_full Current advances and challenges in mpox vaccine development: a global landscape
title_fullStr Current advances and challenges in mpox vaccine development: a global landscape
title_full_unstemmed Current advances and challenges in mpox vaccine development: a global landscape
title_short Current advances and challenges in mpox vaccine development: a global landscape
title_sort current advances and challenges in mpox vaccine development a global landscape
url https://doi.org/10.1177/25151355251314339
work_keys_str_mv AT maryamshafaati currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT shayanforghani currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT amirhosseinshahsavanddavoudi currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT rezasamiee currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT keyhanmohammadi currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT samanehakbarpour currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT arashseifi currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT mohammadrezasalehi currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape
AT maryamzare currentadvancesandchallengesinmpoxvaccinedevelopmentagloballandscape