The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients
The BRAFV600E mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies in different regions. However, the association between the BRAFV600E mutation and clinicopathological features in Chinese PTC patients is unknown. A total of 543 Chinese patients with histologically...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/642046 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562388548714496 |
|---|---|
| author | Li-Bo Yang Lin-Yong Sun Yong Jiang Ying Tang Zhi-Hui Li Hong-Ying Zhang Hong Bu Feng Ye |
| author_facet | Li-Bo Yang Lin-Yong Sun Yong Jiang Ying Tang Zhi-Hui Li Hong-Ying Zhang Hong Bu Feng Ye |
| author_sort | Li-Bo Yang |
| collection | DOAJ |
| description | The BRAFV600E mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies in different regions. However, the association between the BRAFV600E mutation and clinicopathological features in Chinese PTC patients is unknown. A total of 543 Chinese patients with histologically confirmed PTC were enrolled in this study. For the BRAF mutation assay, the target fragments were amplified and sequenced with an ABI 3500 gene analyzer. In 170 of 543 samples (31.3%), the BRAFV600E mutation was detected. In the bivariate analysis, the BRAFV600E mutation showed an association with bilaterality, tumor size, extrathyroidal invasion, and lymph node metastases (LNM). However, in the multivariate analysis, the BRAFV600E mutation was positively related to only tumor size (>1 cm) and extrathyroidal invasion. In addition, the multivariate analysis also showed that the age at diagnosis (<45 y) and tumor size (>1 cm) were independent predictors for LNM. In this study, the BRAFV600E mutation is positively associated with worse prognostic factors, including larger tumor size and the tumor extending to the thyroid capsule or extrathyroidal region; however, it is not an independent predictor for LNM. |
| format | Article |
| id | doaj-art-28ce376ace164af3a8ab9c075315ce88 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-28ce376ace164af3a8ab9c075315ce882025-02-03T01:22:43ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/642046642046The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese PatientsLi-Bo Yang0Lin-Yong Sun1Yong Jiang2Ying Tang3Zhi-Hui Li4Hong-Ying Zhang5Hong Bu6Feng Ye7Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, ChinaThe BRAFV600E mutation is commonly found in papillary thyroid cancers (PTCs) at different frequencies in different regions. However, the association between the BRAFV600E mutation and clinicopathological features in Chinese PTC patients is unknown. A total of 543 Chinese patients with histologically confirmed PTC were enrolled in this study. For the BRAF mutation assay, the target fragments were amplified and sequenced with an ABI 3500 gene analyzer. In 170 of 543 samples (31.3%), the BRAFV600E mutation was detected. In the bivariate analysis, the BRAFV600E mutation showed an association with bilaterality, tumor size, extrathyroidal invasion, and lymph node metastases (LNM). However, in the multivariate analysis, the BRAFV600E mutation was positively related to only tumor size (>1 cm) and extrathyroidal invasion. In addition, the multivariate analysis also showed that the age at diagnosis (<45 y) and tumor size (>1 cm) were independent predictors for LNM. In this study, the BRAFV600E mutation is positively associated with worse prognostic factors, including larger tumor size and the tumor extending to the thyroid capsule or extrathyroidal region; however, it is not an independent predictor for LNM.http://dx.doi.org/10.1155/2015/642046 |
| spellingShingle | Li-Bo Yang Lin-Yong Sun Yong Jiang Ying Tang Zhi-Hui Li Hong-Ying Zhang Hong Bu Feng Ye The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients International Journal of Endocrinology |
| title | The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients |
| title_full | The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients |
| title_fullStr | The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients |
| title_full_unstemmed | The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients |
| title_short | The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients |
| title_sort | clinicopathological features of braf mutated papillary thyroid cancers in chinese patients |
| url | http://dx.doi.org/10.1155/2015/642046 |
| work_keys_str_mv | AT liboyang theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT linyongsun theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT yongjiang theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT yingtang theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT zhihuili theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT hongyingzhang theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT hongbu theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT fengye theclinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT liboyang clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT linyongsun clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT yongjiang clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT yingtang clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT zhihuili clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT hongyingzhang clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT hongbu clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients AT fengye clinicopathologicalfeaturesofbrafmutatedpapillarythyroidcancersinchinesepatients |