The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging
Abstract The Dallas Lifespan Brain Study (DLBS) was designed to integrate brain and cognition across the adult lifespan. Participants (n = 464) were between age 21 and 89 years at time of first assessment and returned approximately every 3.5–5 years for a second (n = 338) and third epoch (n = 224) o...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-04847-7 |
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| author | Denise C. Park Joseph P. Hennessee Evan T. Smith Micaela Y. Chan Xi Chen Marianna Dakanali Michelle E. Farrell Peiying Liu Hanzhang Lu Neil Rofsky Xiankai Sun Carol Tamminga William Moore Kristen M. Kennedy Karen Rodrigue Gagan S. Wig |
| author_facet | Denise C. Park Joseph P. Hennessee Evan T. Smith Micaela Y. Chan Xi Chen Marianna Dakanali Michelle E. Farrell Peiying Liu Hanzhang Lu Neil Rofsky Xiankai Sun Carol Tamminga William Moore Kristen M. Kennedy Karen Rodrigue Gagan S. Wig |
| author_sort | Denise C. Park |
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| description | Abstract The Dallas Lifespan Brain Study (DLBS) was designed to integrate brain and cognition across the adult lifespan. Participants (n = 464) were between age 21 and 89 years at time of first assessment and returned approximately every 3.5–5 years for a second (n = 338) and third epoch (n = 224) of data collection. The three epochs included a comprehensive neuropsychological battery, questionnaires that assessed physical health, psychosocial status, and brain health, structural MRI scans (including T1-weighted imaging and diffusion-weighted imaging), a hypercapnia scan, an arterial spin labeling scan, and four functional fMRI scans. Additionally, measures of amyloid and tau were collected with AV-45 (Florbetapir) and AV-1451 (Flortaucipir). Key innovations were robust sampling of middle-aged participants and inclusion of PET data for amyloid and tau in a cognitively normal sample. This large data set has recently been published on OpenNeuro.org open-access and provides the opportunity for researchers to test many hypotheses about brain and cognition across human adulthood, including longitudinal hypotheses, with these data across a multi-year span. |
| format | Article |
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| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Data |
| spelling | doaj-art-28cb9e630966482dac4b2a6032d0d2b82025-08-20T03:31:45ZengNature PortfolioScientific Data2052-44632025-05-0112111410.1038/s41597-025-04847-7The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive AgingDenise C. Park0Joseph P. Hennessee1Evan T. Smith2Micaela Y. Chan3Xi Chen4Marianna Dakanali5Michelle E. Farrell6Peiying Liu7Hanzhang Lu8Neil Rofsky9Xiankai Sun10Carol Tamminga11William Moore12Kristen M. Kennedy13Karen Rodrigue14Gagan S. Wig15Center for Vital Longevity & Department of Psychology, University of Texas at DallasCenter for Vital Longevity & Department of Psychology, University of Texas at DallasCenter for Vital Longevity & Department of Psychology, University of Texas at DallasCenter for Vital Longevity & Department of Psychology, University of Texas at DallasDepartment of Psychology, SUNY Stony Brook UniversityDepartment of Radiology, University of Texas Southwestern DepartmentDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of MedicineRussell H. Morgan Department of Radiology, Johns Hopkins University School of MedicineDepartment of Radiology and Nuclear Medicine, Icahn School of Medicine at Mount SinaiDepartment of Radiology, University of Texas Southwestern DepartmentDepartment of Psychiatry, University of Texas Southwestern Medical CenterDepartment of Radiology, University of Texas Southwestern DepartmentCenter for Vital Longevity & Department of Psychology, University of Texas at DallasCenter for Vital Longevity & Department of Psychology, University of Texas at DallasCenter for Vital Longevity & Department of Psychology, University of Texas at DallasAbstract The Dallas Lifespan Brain Study (DLBS) was designed to integrate brain and cognition across the adult lifespan. Participants (n = 464) were between age 21 and 89 years at time of first assessment and returned approximately every 3.5–5 years for a second (n = 338) and third epoch (n = 224) of data collection. The three epochs included a comprehensive neuropsychological battery, questionnaires that assessed physical health, psychosocial status, and brain health, structural MRI scans (including T1-weighted imaging and diffusion-weighted imaging), a hypercapnia scan, an arterial spin labeling scan, and four functional fMRI scans. Additionally, measures of amyloid and tau were collected with AV-45 (Florbetapir) and AV-1451 (Flortaucipir). Key innovations were robust sampling of middle-aged participants and inclusion of PET data for amyloid and tau in a cognitively normal sample. This large data set has recently been published on OpenNeuro.org open-access and provides the opportunity for researchers to test many hypotheses about brain and cognition across human adulthood, including longitudinal hypotheses, with these data across a multi-year span.https://doi.org/10.1038/s41597-025-04847-7 |
| spellingShingle | Denise C. Park Joseph P. Hennessee Evan T. Smith Micaela Y. Chan Xi Chen Marianna Dakanali Michelle E. Farrell Peiying Liu Hanzhang Lu Neil Rofsky Xiankai Sun Carol Tamminga William Moore Kristen M. Kennedy Karen Rodrigue Gagan S. Wig The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging Scientific Data |
| title | The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging |
| title_full | The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging |
| title_fullStr | The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging |
| title_full_unstemmed | The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging |
| title_short | The Dallas Lifespan Brain Study: A Comprehensive Adult Lifespan Data Set of Brain and Cognitive Aging |
| title_sort | dallas lifespan brain study a comprehensive adult lifespan data set of brain and cognitive aging |
| url | https://doi.org/10.1038/s41597-025-04847-7 |
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