Inferred bi-directional interactions between vaginal microbiota, metabolome and persistent HPV infection accompanied by high-grade cervical intraepithelial neoplasia

Inferred bi-directional interactions between vaginal microbiota, metabolome and persistent HPV infection accompanied by high-grade cervical intraepithelial neoplasia

Abstract Background Vaginal microbiota (VM) links to the risk of persistent HPV infection and the progression of cervical intraepithelial neoplasia (CIN). However, a comprehensive understanding of concurrent alterations in VM and metabolome associated with that risk remains elusive in population-bas...

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Bibliographic Details
Main Authors: Qin Yang, Wenkui Dai, Di Wu, Ruinan Xu, Changzhong Li, Ruifang Wu, Hui Du
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
Human papillomavirus
Cervical intraepithelial neoplasia
Vaginal microbiota
Lactobacillus
Metabolome
Online Access:https://doi.org/10.1186/s12866-025-04126-w
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