Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population
Abstract Background Metabolic syndrome (MetS) is a multifaceted disorder that significantly elevates the cardiovascular disease risk. The diversity of the combination of its main components, conditioned by genetics and environmental risk factors, contributes to the complexity of this health conditio...
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SpringerOpen
2025-01-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | https://doi.org/10.1186/s43042-025-00637-3 |
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| author | Hamid Farhane Majida Motrane Karchali Soufaine Fatima-Ezzahra Anaibar Aïcha Motrane Said Nassor Abeid Abderraouf Hilali Nourdin Harich |
| author_facet | Hamid Farhane Majida Motrane Karchali Soufaine Fatima-Ezzahra Anaibar Aïcha Motrane Said Nassor Abeid Abderraouf Hilali Nourdin Harich |
| author_sort | Hamid Farhane |
| collection | DOAJ |
| description | Abstract Background Metabolic syndrome (MetS) is a multifaceted disorder that significantly elevates the cardiovascular disease risk. The diversity of the combination of its main components, conditioned by genetics and environmental risk factors, contributes to the complexity of this health condition and increases the difficulty of its diagnosis and treatment. Objective Our study aimed to explore the association between four Alu insertion polymorphisms and the risk of MetS as well as its components in the Doukkala population of Morocco. Methods A case–control study was conducted on 175 cases of MetS and 252 controls. Four Alu insertion polymorphisms (Alu-ACE, Alu-TPA25, Alu-PV92, and Alu-APOA1) were genotyped using Polymerase Chain Reaction followed by direct electrophoresis of its products. Results Our results showed that the Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms are significantly associated with MetS, the patients are characterized by higher frequencies of genotype II (OR = 6.96, 95% CI [4.12–11.75], p < 0.0001) and *Ins allele for Alu-PV92, and DD genotype (OR = 3.32, 95% CI [1.57–7.00], p = 0.001) and *Del allele for Alu-APOA1 compared to controls. Additionally, a significant association was revealed with MetS in men carrying the *Ins allele and the Alu-TPA25 II genotype (OR = 2.11, 95% CI [1.00–4.44], p = 0.0487). Furthermore, our study concluded that the Alu polymorphisms analyzed were linked to several MetS components, such as hyperglycemia, obesity, hypertension, hyperglycemia, and abnormal lipid levels. Conclusion The Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms were associated with an elevated MetS risk and its components in both women and men from the Doukkala population, while the Alu-TPA25 Ins/Del polymorphism are associated only in men with only some components. These findings hold considerable public health implications, indicating that Alu polymorphisms could serve as biomarkers for identifying individuals at risk of developing MetS. |
| format | Article |
| id | doaj-art-28c6e2e14d03407387d08451ace4c515 |
| institution | Kabale University |
| issn | 2090-2441 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj-art-28c6e2e14d03407387d08451ace4c5152025-01-19T12:25:57ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412025-01-0126111110.1186/s43042-025-00637-3Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan populationHamid Farhane0Majida Motrane1Karchali Soufaine2Fatima-Ezzahra Anaibar3Aïcha Motrane4Said Nassor Abeid5Abderraouf Hilali6Nourdin Harich7Laboratory of Anthropogenetics, Biotechnology and Health, Department of Biology, Faculty of Sciences, Chouaïb Doukkali UniversityLaboratory of Anthropogenetics, Biotechnology and Health, Department of Biology, Faculty of Sciences, Chouaïb Doukkali UniversityLaboratory of Anthropogenetics, Biotechnology and Health, Department of Biology, Faculty of Sciences, Chouaïb Doukkali UniversityLaboratory of Anthropogenetics, Biotechnology and Health, Department of Biology, Faculty of Sciences, Chouaïb Doukkali UniversityDiabetes Diagnosis and Treatment Center, Provincial Delegation of Public Health of El JadidaLaboratory of Anthropogenetics, Biotechnology and Health, Department of Biology, Faculty of Sciences, Chouaïb Doukkali UniversityLaboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First UniversityLaboratory of Anthropogenetics, Biotechnology and Health, Department of Biology, Faculty of Sciences, Chouaïb Doukkali UniversityAbstract Background Metabolic syndrome (MetS) is a multifaceted disorder that significantly elevates the cardiovascular disease risk. The diversity of the combination of its main components, conditioned by genetics and environmental risk factors, contributes to the complexity of this health condition and increases the difficulty of its diagnosis and treatment. Objective Our study aimed to explore the association between four Alu insertion polymorphisms and the risk of MetS as well as its components in the Doukkala population of Morocco. Methods A case–control study was conducted on 175 cases of MetS and 252 controls. Four Alu insertion polymorphisms (Alu-ACE, Alu-TPA25, Alu-PV92, and Alu-APOA1) were genotyped using Polymerase Chain Reaction followed by direct electrophoresis of its products. Results Our results showed that the Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms are significantly associated with MetS, the patients are characterized by higher frequencies of genotype II (OR = 6.96, 95% CI [4.12–11.75], p < 0.0001) and *Ins allele for Alu-PV92, and DD genotype (OR = 3.32, 95% CI [1.57–7.00], p = 0.001) and *Del allele for Alu-APOA1 compared to controls. Additionally, a significant association was revealed with MetS in men carrying the *Ins allele and the Alu-TPA25 II genotype (OR = 2.11, 95% CI [1.00–4.44], p = 0.0487). Furthermore, our study concluded that the Alu polymorphisms analyzed were linked to several MetS components, such as hyperglycemia, obesity, hypertension, hyperglycemia, and abnormal lipid levels. Conclusion The Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms were associated with an elevated MetS risk and its components in both women and men from the Doukkala population, while the Alu-TPA25 Ins/Del polymorphism are associated only in men with only some components. These findings hold considerable public health implications, indicating that Alu polymorphisms could serve as biomarkers for identifying individuals at risk of developing MetS.https://doi.org/10.1186/s43042-025-00637-3Alu insertionGenetic polymorphismMetabolic syndromeMoroccan population |
| spellingShingle | Hamid Farhane Majida Motrane Karchali Soufaine Fatima-Ezzahra Anaibar Aïcha Motrane Said Nassor Abeid Abderraouf Hilali Nourdin Harich Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population Egyptian Journal of Medical Human Genetics Alu insertion Genetic polymorphism Metabolic syndrome Moroccan population |
| title | Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population |
| title_full | Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population |
| title_fullStr | Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population |
| title_full_unstemmed | Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population |
| title_short | Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population |
| title_sort | alu insertion polymorphisms and susceptibility to metabolic syndrome in a moroccan population |
| topic | Alu insertion Genetic polymorphism Metabolic syndrome Moroccan population |
| url | https://doi.org/10.1186/s43042-025-00637-3 |
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