Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease
To investigate the clinical features and potential risk factors of active tuberculosis (ATB) in Behçet’s disease (BD), we conducted a case-control study on hospitalized BD patients in our institute from 2010 to 2019. BD patients with ATB were enrolled as the case group. The control group was selecte...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2528676 |
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| author | Yaxu Liu Lifan Zhang Ziyue Zhou Luxi Sun Baotong Zhou Xiaoqing Liu Wenjie Zheng |
| author_facet | Yaxu Liu Lifan Zhang Ziyue Zhou Luxi Sun Baotong Zhou Xiaoqing Liu Wenjie Zheng |
| author_sort | Yaxu Liu |
| collection | DOAJ |
| description | To investigate the clinical features and potential risk factors of active tuberculosis (ATB) in Behçet’s disease (BD), we conducted a case-control study on hospitalized BD patients in our institute from 2010 to 2019. BD patients with ATB were enrolled as the case group. The control group was selected by random number sampling from the remaining BD patients, including those with latent tuberculosis infection, previous tuberculosis, or without tuberculosis. Finally, we reviewed 386 BD patients and identified 21 (5.4%) ATB cases, including four (19.0%) microbiologically confirmed and 17 (81.0%) clinically diagnosed. We found that BD patients with ATB were more prone to have systemic symptoms (fever, night sweating, and unexplained weight loss) and/or symptoms related to the infection site. Multivariate logistic regression analysis revealed that erythrocyte sedimentation rate ESR>60 mm/h (OR=13.710, 95% CI (1.101, 170.702)), increased IgG (OR=1.226, 95% CI (1.001, 1.502)), and positive T-SPOT.TB (OR=7.793, 95% CI (1.312, 48.464), for 24-200 SFC/106PBMC; OR=17.705 95% CI (2.503, 125.260), for >200 SFC/106PBMC) were potential risk factors for ATB in BD patients. Our study suggested that when BD patients have systemic symptoms with significantly elevated TB-SPOT, the diagnosis of ATB should be considered. |
| format | Article |
| id | doaj-art-28c5462e582242b7addfbc7a8dbf27e7 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-28c5462e582242b7addfbc7a8dbf27e72025-02-03T06:05:28ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/25286762528676Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s DiseaseYaxu Liu0Lifan Zhang1Ziyue Zhou2Luxi Sun3Baotong Zhou4Xiaoqing Liu5Wenjie Zheng6Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, ChinaDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, ChinaTo investigate the clinical features and potential risk factors of active tuberculosis (ATB) in Behçet’s disease (BD), we conducted a case-control study on hospitalized BD patients in our institute from 2010 to 2019. BD patients with ATB were enrolled as the case group. The control group was selected by random number sampling from the remaining BD patients, including those with latent tuberculosis infection, previous tuberculosis, or without tuberculosis. Finally, we reviewed 386 BD patients and identified 21 (5.4%) ATB cases, including four (19.0%) microbiologically confirmed and 17 (81.0%) clinically diagnosed. We found that BD patients with ATB were more prone to have systemic symptoms (fever, night sweating, and unexplained weight loss) and/or symptoms related to the infection site. Multivariate logistic regression analysis revealed that erythrocyte sedimentation rate ESR>60 mm/h (OR=13.710, 95% CI (1.101, 170.702)), increased IgG (OR=1.226, 95% CI (1.001, 1.502)), and positive T-SPOT.TB (OR=7.793, 95% CI (1.312, 48.464), for 24-200 SFC/106PBMC; OR=17.705 95% CI (2.503, 125.260), for >200 SFC/106PBMC) were potential risk factors for ATB in BD patients. Our study suggested that when BD patients have systemic symptoms with significantly elevated TB-SPOT, the diagnosis of ATB should be considered.http://dx.doi.org/10.1155/2020/2528676 |
| spellingShingle | Yaxu Liu Lifan Zhang Ziyue Zhou Luxi Sun Baotong Zhou Xiaoqing Liu Wenjie Zheng Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease Journal of Immunology Research |
| title | Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease |
| title_full | Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease |
| title_fullStr | Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease |
| title_full_unstemmed | Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease |
| title_short | Clinical Features and Risk Factors of Active Tuberculosis in Patients with Behçet’s Disease |
| title_sort | clinical features and risk factors of active tuberculosis in patients with behcet s disease |
| url | http://dx.doi.org/10.1155/2020/2528676 |
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