Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism
Background: The relationship between diet and venous thromboembolism (VTE) remains unclear, and the joint effects of diet patterns and genetic susceptibility on VTE risk are unknown. Objectives: Investigate the independent and joint effects of Dietary Approaches to Stop Hypertension (DASH) diet adhe...
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Elsevier
2025-02-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S247503792500055X |
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| author | Si Li Minghui Jiang Yunlong Guan Xi Cao Zhonghe Shao Jun Deng Xingjie Hao |
| author_facet | Si Li Minghui Jiang Yunlong Guan Xi Cao Zhonghe Shao Jun Deng Xingjie Hao |
| author_sort | Si Li |
| collection | DOAJ |
| description | Background: The relationship between diet and venous thromboembolism (VTE) remains unclear, and the joint effects of diet patterns and genetic susceptibility on VTE risk are unknown. Objectives: Investigate the independent and joint effects of Dietary Approaches to Stop Hypertension (DASH) diet adherence and polygenic risk scores (PRS) on VTE risk. Methods: A total of 411,539 UK Biobank participants were included. DASH scores were calculated using Food Frequency Questionnaires, and PRS quantified genetic risk. Cox proportional hazard models estimated hazard ratios (HRs) for VTE, assessing interactions between the DASH diet and genetic susceptibility. Results: During a median follow-up of 13.4 years, 10,543 participants were diagnosed with VTE. Higher DASH scores were associated with a lower VTE risk (HR, 0.87; 95% CI, 0.82-0.92). A low-adherent DASH diet combined with high-genetic risk had the highest VTE risk (HR, 2.78; 95% CI, 2.47-3.14). High DASH scores reduced VTE risk in high-genetic-risk individuals (HR, 0.84; 95% CI, 0.76-0.92). Sex-specific associations were detected in the joint effect and interaction of DASH scores and PRS. Notably, high DASH scores can offset moderate genetic risk among men (HR, 0.79; 95% CI, 0.67-0.94). There were additive interactions between DASH scores and high genetic risk in total subjects and men, while not observed in women. Conclusion: The DASH diet is associated with reduced VTE risk and can partially offset genetic predisposition. Low adherence to the DASH diet increases VTE risk, particularly in high-genetic-risk individuals. The protective effect of high DASH scores against genetic risks for VTE is more pronounced in males. Precision medicine should consider both diet and genetics for VTE prevention. |
| format | Article |
| id | doaj-art-28bf0aa7f61c4f439a2a74abf5d0b522 |
| institution | OA Journals |
| issn | 2475-0379 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj-art-28bf0aa7f61c4f439a2a74abf5d0b5222025-08-20T02:12:03ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792025-02-019210273110.1016/j.rpth.2025.102731Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolismSi Li0Minghui Jiang1Yunlong Guan2Xi Cao3Zhonghe Shao4Jun Deng5Xingjie Hao6Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Hematology, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Jun Deng, Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, 430022, Wuhan, Hubei, China.Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Correspondence Xingjie Hao, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, 430030, Wuhan, Hubei, China.Background: The relationship between diet and venous thromboembolism (VTE) remains unclear, and the joint effects of diet patterns and genetic susceptibility on VTE risk are unknown. Objectives: Investigate the independent and joint effects of Dietary Approaches to Stop Hypertension (DASH) diet adherence and polygenic risk scores (PRS) on VTE risk. Methods: A total of 411,539 UK Biobank participants were included. DASH scores were calculated using Food Frequency Questionnaires, and PRS quantified genetic risk. Cox proportional hazard models estimated hazard ratios (HRs) for VTE, assessing interactions between the DASH diet and genetic susceptibility. Results: During a median follow-up of 13.4 years, 10,543 participants were diagnosed with VTE. Higher DASH scores were associated with a lower VTE risk (HR, 0.87; 95% CI, 0.82-0.92). A low-adherent DASH diet combined with high-genetic risk had the highest VTE risk (HR, 2.78; 95% CI, 2.47-3.14). High DASH scores reduced VTE risk in high-genetic-risk individuals (HR, 0.84; 95% CI, 0.76-0.92). Sex-specific associations were detected in the joint effect and interaction of DASH scores and PRS. Notably, high DASH scores can offset moderate genetic risk among men (HR, 0.79; 95% CI, 0.67-0.94). There were additive interactions between DASH scores and high genetic risk in total subjects and men, while not observed in women. Conclusion: The DASH diet is associated with reduced VTE risk and can partially offset genetic predisposition. Low adherence to the DASH diet increases VTE risk, particularly in high-genetic-risk individuals. The protective effect of high DASH scores against genetic risks for VTE is more pronounced in males. Precision medicine should consider both diet and genetics for VTE prevention.http://www.sciencedirect.com/science/article/pii/S247503792500055Xadditive interactiongene-diet interactiongenetic susceptibilityUK Biobankvenous thromboembolism |
| spellingShingle | Si Li Minghui Jiang Yunlong Guan Xi Cao Zhonghe Shao Jun Deng Xingjie Hao Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism Research and Practice in Thrombosis and Haemostasis additive interaction gene-diet interaction genetic susceptibility UK Biobank venous thromboembolism |
| title | Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism |
| title_full | Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism |
| title_fullStr | Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism |
| title_full_unstemmed | Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism |
| title_short | Association between genetic risk and adherence to the Dietary Approaches to Stop Hypertension diet for developing venous thromboembolism |
| title_sort | association between genetic risk and adherence to the dietary approaches to stop hypertension diet for developing venous thromboembolism |
| topic | additive interaction gene-diet interaction genetic susceptibility UK Biobank venous thromboembolism |
| url | http://www.sciencedirect.com/science/article/pii/S247503792500055X |
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