del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial: protocol for a multicentre randomised controlled trial in children undergoing cardiac surgery

del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial: protocol for a multicentre randomised controlled trial in children undergoing cardiac surgery

Introduction Myocardial protection against ischaemia–reperfusion injury is a key determinant of heart function and outcome following cardiac surgery in children. However, myocardial injury still occurs routinely following aortic cross-clamping, as demonstrated by the ubiquitous rise in circulating t...

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Main Authors: Massimo Caputo, Serban Stoica, Kelly Handley, Timothy J Jones, Nigel E Drury, Barnaby R Scholefield, Martin Kostolny, Alex Robertson, Yongzhong Sun, Carin Van Doorn, Warwick B Dunn, John V Pappachan, Hugh Jarrett, Carly Tooke, Tina Griffin, Indie Bilkhoo
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/4/e102029.full
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