Overview of the Current Challenges in Pulmonary Coccidioidomycosis
Coccidioidomycosis is a disease caused by soil fungi of the genus <i>Coccidioides</i>, divided genetically into <i>Coccidioides immitis</i> (California isolates) and <i>Coccidioides posadasii</i> (isolates outside California). Coccidioidomycosis is transmitted thr...
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2024-10-01
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| author | Mohamed A. Fayed Timothy M. Evans Eyad Almasri Kathryn L. Bilello Robert Libke Michael W. Peterson |
| author_facet | Mohamed A. Fayed Timothy M. Evans Eyad Almasri Kathryn L. Bilello Robert Libke Michael W. Peterson |
| author_sort | Mohamed A. Fayed |
| collection | DOAJ |
| description | Coccidioidomycosis is a disease caused by soil fungi of the genus <i>Coccidioides</i>, divided genetically into <i>Coccidioides immitis</i> (California isolates) and <i>Coccidioides posadasii</i> (isolates outside California). Coccidioidomycosis is transmitted through the inhalation of fungal spores, arthroconidia, which can cause disease in susceptible mammalian hosts, including humans. Coccidioidomycosis is endemic to the western part of the United States of America, including the central valley of California, Arizona, New Mexico, and parts of western Texas. Cases have been reported in other regions in different states, and endemic pockets are present in these states. The incidence of reported cases of coccidioidomycosis has notably increased since it became reportable in 1995. Clinically, the infection ranges from asymptomatic to fatal disease due to pneumonia or disseminated states. The recognition of coccidioidomycosis can be challenging, as it frequently mimics bacterial community-acquired pneumonia. The diagnosis of coccidioidomycosis is frequently dependent on serologic testing, the results of which can take several days or longer to obtain. Coccidioidomycosis continues to present challenges for clinicians, and suspected cases can be easily missed. The challenges of coccidioidomycosis disease, from presentation to diagnosis to treatment, remain a hurdle for clinicians, and further research is needed to address these challenges. |
| format | Article |
| id | doaj-art-28bbeb613f2d4477b28ba8cea95d7475 |
| institution | OA Journals |
| issn | 2309-608X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Journal of Fungi |
| spelling | doaj-art-28bbeb613f2d4477b28ba8cea95d74752025-08-20T02:10:54ZengMDPI AGJournal of Fungi2309-608X2024-10-01101072410.3390/jof10100724Overview of the Current Challenges in Pulmonary CoccidioidomycosisMohamed A. Fayed0Timothy M. Evans1Eyad Almasri2Kathryn L. Bilello3Robert Libke4Michael W. Peterson5Pulmonary Critical Care Division, University of California San Francisco, Fresno Campus, Fresno, CA 93701, USAPulmonary Critical Care Division, University of California San Francisco, Fresno Campus, Fresno, CA 93701, USAPulmonary Critical Care Division, University of California San Francisco, Fresno Campus, Fresno, CA 93701, USAPulmonary Critical Care Division, University of California San Francisco, Fresno Campus, Fresno, CA 93701, USAInfectious Disease Division, University of California San Francisco, Fresno Campus, Fresno, CA 93701, USAPulmonary Critical Care Division, University of California San Francisco, Fresno Campus, Fresno, CA 93701, USACoccidioidomycosis is a disease caused by soil fungi of the genus <i>Coccidioides</i>, divided genetically into <i>Coccidioides immitis</i> (California isolates) and <i>Coccidioides posadasii</i> (isolates outside California). Coccidioidomycosis is transmitted through the inhalation of fungal spores, arthroconidia, which can cause disease in susceptible mammalian hosts, including humans. Coccidioidomycosis is endemic to the western part of the United States of America, including the central valley of California, Arizona, New Mexico, and parts of western Texas. Cases have been reported in other regions in different states, and endemic pockets are present in these states. The incidence of reported cases of coccidioidomycosis has notably increased since it became reportable in 1995. Clinically, the infection ranges from asymptomatic to fatal disease due to pneumonia or disseminated states. The recognition of coccidioidomycosis can be challenging, as it frequently mimics bacterial community-acquired pneumonia. The diagnosis of coccidioidomycosis is frequently dependent on serologic testing, the results of which can take several days or longer to obtain. Coccidioidomycosis continues to present challenges for clinicians, and suspected cases can be easily missed. The challenges of coccidioidomycosis disease, from presentation to diagnosis to treatment, remain a hurdle for clinicians, and further research is needed to address these challenges.https://www.mdpi.com/2309-608X/10/10/724coccidioidomycosisvalley feverpulmonary noduleslung masspyopneumothorax |
| spellingShingle | Mohamed A. Fayed Timothy M. Evans Eyad Almasri Kathryn L. Bilello Robert Libke Michael W. Peterson Overview of the Current Challenges in Pulmonary Coccidioidomycosis Journal of Fungi coccidioidomycosis valley fever pulmonary nodules lung mass pyopneumothorax |
| title | Overview of the Current Challenges in Pulmonary Coccidioidomycosis |
| title_full | Overview of the Current Challenges in Pulmonary Coccidioidomycosis |
| title_fullStr | Overview of the Current Challenges in Pulmonary Coccidioidomycosis |
| title_full_unstemmed | Overview of the Current Challenges in Pulmonary Coccidioidomycosis |
| title_short | Overview of the Current Challenges in Pulmonary Coccidioidomycosis |
| title_sort | overview of the current challenges in pulmonary coccidioidomycosis |
| topic | coccidioidomycosis valley fever pulmonary nodules lung mass pyopneumothorax |
| url | https://www.mdpi.com/2309-608X/10/10/724 |
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