Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia
Landiolol, an ultra-short-acting β1-selective blocker, is more effective in controlling heart rate compared with digoxin in patients with atrial tachyarrhythmias and left ventricular dysfunction. However, the effect of atrial tachyarrhythmia type on the effectiveness of landiolol remains unknown. He...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/60/11/1782 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850226749552459776 |
|---|---|
| author | Kengo Ayabe Tomoyoshi Komiyama Hiroyuki Takekawa Honsa Kang Yasuaki Tsumagari Miwa Ito Keiichi Ashikaga Yoshisato Shibata |
| author_facet | Kengo Ayabe Tomoyoshi Komiyama Hiroyuki Takekawa Honsa Kang Yasuaki Tsumagari Miwa Ito Keiichi Ashikaga Yoshisato Shibata |
| author_sort | Kengo Ayabe |
| collection | DOAJ |
| description | Landiolol, an ultra-short-acting β1-selective blocker, is more effective in controlling heart rate compared with digoxin in patients with atrial tachyarrhythmias and left ventricular dysfunction. However, the effect of atrial tachyarrhythmia type on the effectiveness of landiolol remains unknown. Hence, this study aimed to evaluate the effectiveness of landiolol in patients with atrial fibrillation (AF) and atrial tachycardia (AT), not limited to those with heart failure with a reduced ejection fraction. To this end, we evaluated the efficacy and safety of landiolol in managing tachycardiac AF and tachycardiac atrial flutter/AT in 44 patients with reduced left ventricular function. We found that while landiolol was effective in managing patients with AF and heart failure with a preserved or mid-range ejection fraction, however, it might be more challenging to control heart rate in patients with AT using a similar dosage of landiolol. |
| format | Article |
| id | doaj-art-28bb64c68c2d4968bdbfc0013ef21fac |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-28bb64c68c2d4968bdbfc0013ef21fac2025-08-20T02:04:59ZengMDPI AGMedicina1010-660X1648-91442024-10-016011178210.3390/medicina60111782Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial TachycardiaKengo Ayabe0Tomoyoshi Komiyama1Hiroyuki Takekawa2Honsa Kang3Yasuaki Tsumagari4Miwa Ito5Keiichi Ashikaga6Yoshisato Shibata7Cardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, JapanDepartment of Clinical Pharmacology, Tokai University School of Medicine, Isehara 259-1193, JapanCardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, JapanFukuoka City Hospital Cardiology Department, Fukuoka 812-0046, JapanCardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, JapanCardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, JapanCardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, JapanCardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, JapanLandiolol, an ultra-short-acting β1-selective blocker, is more effective in controlling heart rate compared with digoxin in patients with atrial tachyarrhythmias and left ventricular dysfunction. However, the effect of atrial tachyarrhythmia type on the effectiveness of landiolol remains unknown. Hence, this study aimed to evaluate the effectiveness of landiolol in patients with atrial fibrillation (AF) and atrial tachycardia (AT), not limited to those with heart failure with a reduced ejection fraction. To this end, we evaluated the efficacy and safety of landiolol in managing tachycardiac AF and tachycardiac atrial flutter/AT in 44 patients with reduced left ventricular function. We found that while landiolol was effective in managing patients with AF and heart failure with a preserved or mid-range ejection fraction, however, it might be more challenging to control heart rate in patients with AT using a similar dosage of landiolol.https://www.mdpi.com/1648-9144/60/11/1782landiololHFpEFHFmrEFHFrEFβ-blocker |
| spellingShingle | Kengo Ayabe Tomoyoshi Komiyama Hiroyuki Takekawa Honsa Kang Yasuaki Tsumagari Miwa Ito Keiichi Ashikaga Yoshisato Shibata Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia Medicina landiolol HFpEF HFmrEF HFrEF β-blocker |
| title | Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia |
| title_full | Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia |
| title_fullStr | Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia |
| title_full_unstemmed | Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia |
| title_short | Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia |
| title_sort | differential effects of landiolol in patients with atrial fibrillation and atrial tachycardia |
| topic | landiolol HFpEF HFmrEF HFrEF β-blocker |
| url | https://www.mdpi.com/1648-9144/60/11/1782 |
| work_keys_str_mv | AT kengoayabe differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT tomoyoshikomiyama differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT hiroyukitakekawa differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT honsakang differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT yasuakitsumagari differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT miwaito differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT keiichiashikaga differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia AT yoshisatoshibata differentialeffectsoflandiololinpatientswithatrialfibrillationandatrialtachycardia |