The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer
One of the leading causes of cancer-related mortality globally is non-small cell lung cancer (NSCLC). It has become a significant public health concern due to its rising incidence rate and fatality. Tumor-associated macrophage (TAM) is important in the tumor microenvironment (TME) of NSCLC because t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1541104/full |
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| author | Jiazheng Sun Sirui Zhou Yalu Sun Yulan Zeng |
| author_facet | Jiazheng Sun Sirui Zhou Yalu Sun Yulan Zeng |
| author_sort | Jiazheng Sun |
| collection | DOAJ |
| description | One of the leading causes of cancer-related mortality globally is non-small cell lung cancer (NSCLC). It has become a significant public health concern due to its rising incidence rate and fatality. Tumor-associated macrophage (TAM) is important in the tumor microenvironment (TME) of NSCLC because they have an impact on the development, metastasis, and incidence of tumors. As a crucial element of the TME, TAM contributes to tumor immune evasion, facilitates tumor proliferation and metastasis, and modulates tumor angiogenesis, immunosuppression, and treatment resistance through the secretion of diverse cytokines, chemokines, and growth factors. Consequently, TAM assumes a multifaceted and intricate function in the onset, progression, and therapeutic response of NSCLC, serving as a crucial focal point for comprehending the tumor microenvironment and formulating novel therapeutic methods. The study aims to review the biological properties and potential processes of TAM in NSCLC, investigate its involvement in the clinical of NSCLC patients, and discuss its potential as a therapeutic target. |
| format | Article |
| id | doaj-art-28b8eaf07ce64f028eb1dae9614ef4b4 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-28b8eaf07ce64f028eb1dae9614ef4b42025-08-20T03:51:59ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15411041541104The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancerJiazheng Sun0Sirui Zhou1Yalu Sun2Yulan Zeng3Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaLiyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaAffiliated Hospital of Jining Medical University, Jining, ChinaLiyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaOne of the leading causes of cancer-related mortality globally is non-small cell lung cancer (NSCLC). It has become a significant public health concern due to its rising incidence rate and fatality. Tumor-associated macrophage (TAM) is important in the tumor microenvironment (TME) of NSCLC because they have an impact on the development, metastasis, and incidence of tumors. As a crucial element of the TME, TAM contributes to tumor immune evasion, facilitates tumor proliferation and metastasis, and modulates tumor angiogenesis, immunosuppression, and treatment resistance through the secretion of diverse cytokines, chemokines, and growth factors. Consequently, TAM assumes a multifaceted and intricate function in the onset, progression, and therapeutic response of NSCLC, serving as a crucial focal point for comprehending the tumor microenvironment and formulating novel therapeutic methods. The study aims to review the biological properties and potential processes of TAM in NSCLC, investigate its involvement in the clinical of NSCLC patients, and discuss its potential as a therapeutic target.https://www.frontiersin.org/articles/10.3389/fmed.2025.1541104/fulltumor-associated macrophagenon-small cell lung cancertherapeutic targetsimmune escapetumor microenvironment |
| spellingShingle | Jiazheng Sun Sirui Zhou Yalu Sun Yulan Zeng The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer Frontiers in Medicine tumor-associated macrophage non-small cell lung cancer therapeutic targets immune escape tumor microenvironment |
| title | The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer |
| title_full | The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer |
| title_fullStr | The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer |
| title_full_unstemmed | The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer |
| title_short | The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer |
| title_sort | clinical significance and potential therapeutic target of tumor associated macrophage in non small cell lung cancer |
| topic | tumor-associated macrophage non-small cell lung cancer therapeutic targets immune escape tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1541104/full |
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