Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China
Background There have been some shifts in the frequency and distribution of biopsy-proven renal diseases in China over recent years. The aim of the study was to investigate the changing spectrum of renal diseases from the view of kidney biopsy data in a single center of China.Methods and results A t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2381614 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850140106361405440 |
|---|---|
| author | Yujia Wang Liyin Zhang Li Yuan Qionghong Xie Shaojun Liu Chuan-ming Hao |
| author_facet | Yujia Wang Liyin Zhang Li Yuan Qionghong Xie Shaojun Liu Chuan-ming Hao |
| author_sort | Yujia Wang |
| collection | DOAJ |
| description | Background There have been some shifts in the frequency and distribution of biopsy-proven renal diseases in China over recent years. The aim of the study was to investigate the changing spectrum of renal diseases from the view of kidney biopsy data in a single center of China.Methods and results A total of 10,996 cases of native renal biopsies from patients aged ≥15 years old in Huashan Hospital, Fudan University, between 2008 and 2018 were analyzed retrospectively. The results showed that primary glomerular nephropathy (PGN) remained the most common biopsy-proven renal disease (69.42% of total), with IgA nephropathy (IgAN) accounting for 44.40% of PGN, membranous nephropathy (MN) for 28.55%, minimal change disease (MCD) for 13.26% and focal segmental glomerulosclerosis (FSGS) for 8.00%. During the study period, the proportion of MN in PGN appeared an increasing tendency, while that of IgAN and MCD remained stable and that of FSGS showed a decline. Secondary glomerular nephropathy (SGN) constituted 21.54% of total cases, among which the leading two diseases were lupus nephritis (LN) and Henoch-Schonlein purpura nephritis (HSN) which accounted for 41.08% and 19.11% respectively.Conclusions The 11-year retrospective study revealed that PGN was the predominant histologic diagnosis among patients undergoing renal biopsy and the most frequent type of PGN remained to be IgAN, followed by MN which increased dramatically. |
| format | Article |
| id | doaj-art-28b7cb8755ef46b0846269d812e8fb4a |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-28b7cb8755ef46b0846269d812e8fb4a2025-08-20T02:29:58ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2381614Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in ChinaYujia Wang0Liyin Zhang1Li Yuan2Qionghong Xie3Shaojun Liu4Chuan-ming Hao5Department of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai, ChinaDepartment of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai, ChinaDepartment of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai, ChinaDepartment of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai, ChinaDepartment of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai, ChinaDepartment of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai, ChinaBackground There have been some shifts in the frequency and distribution of biopsy-proven renal diseases in China over recent years. The aim of the study was to investigate the changing spectrum of renal diseases from the view of kidney biopsy data in a single center of China.Methods and results A total of 10,996 cases of native renal biopsies from patients aged ≥15 years old in Huashan Hospital, Fudan University, between 2008 and 2018 were analyzed retrospectively. The results showed that primary glomerular nephropathy (PGN) remained the most common biopsy-proven renal disease (69.42% of total), with IgA nephropathy (IgAN) accounting for 44.40% of PGN, membranous nephropathy (MN) for 28.55%, minimal change disease (MCD) for 13.26% and focal segmental glomerulosclerosis (FSGS) for 8.00%. During the study period, the proportion of MN in PGN appeared an increasing tendency, while that of IgAN and MCD remained stable and that of FSGS showed a decline. Secondary glomerular nephropathy (SGN) constituted 21.54% of total cases, among which the leading two diseases were lupus nephritis (LN) and Henoch-Schonlein purpura nephritis (HSN) which accounted for 41.08% and 19.11% respectively.Conclusions The 11-year retrospective study revealed that PGN was the predominant histologic diagnosis among patients undergoing renal biopsy and the most frequent type of PGN remained to be IgAN, followed by MN which increased dramatically.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2381614Kidney diseaseprimary glomerular nephropathysecondary glomerular nephropathyrenal biopsyChina |
| spellingShingle | Yujia Wang Liyin Zhang Li Yuan Qionghong Xie Shaojun Liu Chuan-ming Hao Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China Renal Failure Kidney disease primary glomerular nephropathy secondary glomerular nephropathy renal biopsy China |
| title | Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China |
| title_full | Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China |
| title_fullStr | Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China |
| title_full_unstemmed | Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China |
| title_short | Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China |
| title_sort | changes in the spectrum of biopsy proven renal diseases over 11 years a single center study in china |
| topic | Kidney disease primary glomerular nephropathy secondary glomerular nephropathy renal biopsy China |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2381614 |
| work_keys_str_mv | AT yujiawang changesinthespectrumofbiopsyprovenrenaldiseasesover11yearsasinglecenterstudyinchina AT liyinzhang changesinthespectrumofbiopsyprovenrenaldiseasesover11yearsasinglecenterstudyinchina AT liyuan changesinthespectrumofbiopsyprovenrenaldiseasesover11yearsasinglecenterstudyinchina AT qionghongxie changesinthespectrumofbiopsyprovenrenaldiseasesover11yearsasinglecenterstudyinchina AT shaojunliu changesinthespectrumofbiopsyprovenrenaldiseasesover11yearsasinglecenterstudyinchina AT chuanminghao changesinthespectrumofbiopsyprovenrenaldiseasesover11yearsasinglecenterstudyinchina |