Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin

Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin

By virtue of their ability to bind different growth factors, morphogens and extracellular matrix proteins, heparan sulfate proteoglycans (HSPGs) play a determinant role in cancer cell differentiation and migration. Despite a strong conceptual basis and promising preclinical results, clinical trials...

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Bibliographic Details
Main Authors: Lorenzo Depau, Jlenia Brunetti, Chiara Falciani, Elisabetta Mandarini, Marta Zanchi, Maria Francesca Paolocci, Marta Garfì, Alessandro Pini, Luisa Bracci
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
heparan sulfate proteoglycans
cancer cell migration
peptide
extracellular matrix
tumor target
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1505680/full
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