Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin
Background/Objectives: Curcumin is well known for its great anti-inflammatory and antioxidant efficacy, representing a potential strategy for the treatment of respiratory disorders. However, several drawbacks, such as chemical instability, poor water solubility and rapid metabolism, result in low bi...
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MDPI AG
2024-12-01
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| author | Luca Casula Emanuela Fabiola Craparo Eleonora Lai Cinzia Scialabba Donatella Valenti Michele Schlich Chiara Sinico Gennara Cavallaro Francesco Lai |
| author_facet | Luca Casula Emanuela Fabiola Craparo Eleonora Lai Cinzia Scialabba Donatella Valenti Michele Schlich Chiara Sinico Gennara Cavallaro Francesco Lai |
| author_sort | Luca Casula |
| collection | DOAJ |
| description | Background/Objectives: Curcumin is well known for its great anti-inflammatory and antioxidant efficacy, representing a potential strategy for the treatment of respiratory disorders. However, several drawbacks, such as chemical instability, poor water solubility and rapid metabolism, result in low bioavailability, limiting its clinical applications. In this study, curcumin nanocrystals were incorporated into mannitol-based microparticles to obtain an inhalable dry powder. Methods: A curcumin nanosuspension was produced by wet-ball media milling and thoroughly characterized. Spray drying was then used to produce mannitol microparticles incorporating curcumin nanocrystals. In vitro release/dissolution tests were carried out in simulated lung fluids, and the aerosolization properties were evaluated using a Next-Generation Impactor (NGI, Apparatus E Ph. Eu.). Results: The incorporation of curcumin nanocrystals into mannitol-based microparticles influenced their morphological properties, such as geometric diameters, and flowability. Despite these changes, nebulization studies confirmed optimal MMAD values (<5 µm), while multi-step dissolution/release studies evidenced the influence of mannitol. Conclusions: The developed curcumin nanocrystals-loaded mannitol microparticles show promise as an inhalable treatment for respiratory diseases, combining effective aerodynamic properties with controlled drug release. |
| format | Article |
| id | doaj-art-28b142bc035f4fd584bb4bfd2e1d5a55 |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
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| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-28b142bc035f4fd584bb4bfd2e1d5a552025-08-20T02:56:54ZengMDPI AGPharmaceuticals1424-82472024-12-011712170810.3390/ph17121708Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of CurcuminLuca Casula0Emanuela Fabiola Craparo1Eleonora Lai2Cinzia Scialabba3Donatella Valenti4Michele Schlich5Chiara Sinico6Gennara Cavallaro7Francesco Lai8Department of Life and Environmental Sciences, University of Cagliari, S.P. Monserrato-Sestu km 0.700, Monserrato, 09042 Cagliari, ItalyLaboratory of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, S.P. Monserrato-Sestu km 0.700, Monserrato, 09042 Cagliari, ItalyLaboratory of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, S.P. Monserrato-Sestu km 0.700, Monserrato, 09042 Cagliari, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, S.P. Monserrato-Sestu km 0.700, Monserrato, 09042 Cagliari, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, S.P. Monserrato-Sestu km 0.700, Monserrato, 09042 Cagliari, ItalyLaboratory of Biocompatible Polymers, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, S.P. Monserrato-Sestu km 0.700, Monserrato, 09042 Cagliari, ItalyBackground/Objectives: Curcumin is well known for its great anti-inflammatory and antioxidant efficacy, representing a potential strategy for the treatment of respiratory disorders. However, several drawbacks, such as chemical instability, poor water solubility and rapid metabolism, result in low bioavailability, limiting its clinical applications. In this study, curcumin nanocrystals were incorporated into mannitol-based microparticles to obtain an inhalable dry powder. Methods: A curcumin nanosuspension was produced by wet-ball media milling and thoroughly characterized. Spray drying was then used to produce mannitol microparticles incorporating curcumin nanocrystals. In vitro release/dissolution tests were carried out in simulated lung fluids, and the aerosolization properties were evaluated using a Next-Generation Impactor (NGI, Apparatus E Ph. Eu.). Results: The incorporation of curcumin nanocrystals into mannitol-based microparticles influenced their morphological properties, such as geometric diameters, and flowability. Despite these changes, nebulization studies confirmed optimal MMAD values (<5 µm), while multi-step dissolution/release studies evidenced the influence of mannitol. Conclusions: The developed curcumin nanocrystals-loaded mannitol microparticles show promise as an inhalable treatment for respiratory diseases, combining effective aerodynamic properties with controlled drug release.https://www.mdpi.com/1424-8247/17/12/1708nano into micronanosuspensioninhalable microparticlescurcuminpulmonary delivery |
| spellingShingle | Luca Casula Emanuela Fabiola Craparo Eleonora Lai Cinzia Scialabba Donatella Valenti Michele Schlich Chiara Sinico Gennara Cavallaro Francesco Lai Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin Pharmaceuticals nano into micro nanosuspension inhalable microparticles curcumin pulmonary delivery |
| title | Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin |
| title_full | Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin |
| title_fullStr | Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin |
| title_full_unstemmed | Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin |
| title_short | Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin |
| title_sort | encapsulation of nanocrystals in mannitol based inhalable microparticles via spray drying a promising strategy for lung delivery of curcumin |
| topic | nano into micro nanosuspension inhalable microparticles curcumin pulmonary delivery |
| url | https://www.mdpi.com/1424-8247/17/12/1708 |
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