Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study
Abstract Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and effective hemodynamic support. Current mecha...
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Wiley
2025-03-01
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| Online Access: | https://doi.org/10.1002/advs.202412120 |
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| author | Adrienne Ji James Davies Phuoc Thien Phan Chi Cong Nguyen Bibhu Sharma Kefan Zhu Emanuele Nicotra Jingjing Wan Hoang‐Phuong Phan Christopher Hayward Nigel H. Lovell Thanh Nho Do |
| author_facet | Adrienne Ji James Davies Phuoc Thien Phan Chi Cong Nguyen Bibhu Sharma Kefan Zhu Emanuele Nicotra Jingjing Wan Hoang‐Phuong Phan Christopher Hayward Nigel H. Lovell Thanh Nho Do |
| author_sort | Adrienne Ji |
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| description | Abstract Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and effective hemodynamic support. Current mechanical assistive devices, such as intra‐aortic balloon pumps (IABP) and extracorporeal membrane oxygenation (ECMO), offer temporary stabilization but are limited to short‐term use due to risks associated with prolonged blood contact. This research presents a novel proof‐of‐concept soft robotic device designed with the aim of achieving low‐risk, medium‐term counterpulsation therapy. The device employs a nature‐inspired growing mechanism for potentially minimally invasive deployment around the ascending aorta, coupled with hydraulic artificial muscles for aortic compression. It demonstrated a maximum stroke volume of 16.48 ± 0.21 mL (SD, n = 5), outperforming all other non‐pneumatic extra‐aortic devices. In addition, in vitro tests with a mock circulation loop (MCL) show a drop in aortic end‐diastolic pressure by 6.32 mmHg and enhance coronary flow under mild aortic stenosis, which attenuate the device's assistive effect. These findings highlight the device's strong potential for optimization as a promising solution to improve outcomes for hemodynamically unstable HF patients. |
| format | Article |
| id | doaj-art-28ae7af40eb44bd2942a16fc9ce5cbd5 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-28ae7af40eb44bd2942a16fc9ce5cbd52025-08-20T02:24:47ZengWileyAdvanced Science2198-38442025-03-011211n/an/a10.1002/advs.202412120Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility StudyAdrienne Ji0James Davies1Phuoc Thien Phan2Chi Cong Nguyen3Bibhu Sharma4Kefan Zhu5Emanuele Nicotra6Jingjing Wan7Hoang‐Phuong Phan8Christopher Hayward9Nigel H. Lovell10Thanh Nho Do11Graduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaSchool of Mechanical and Manufacturing Engineering Faculty of Engineering UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaDepartment of Cardiology St Vincent's Hospital Sydney NSW 2010 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaGraduate School of Biomedical Engineering, Faculty of Engineering, and Tyree Institute of Health Engineering (IHealthE) UNSW Sydney Kensington Campus Sydney NSW 2052 AustraliaAbstract Hemodynamic stabilization is crucial in managing acute cardiac events, where compromised blood flow can lead to severe complications and increased mortality. Conditions like decompensated heart failure (HF) and cardiogenic shock require rapid and effective hemodynamic support. Current mechanical assistive devices, such as intra‐aortic balloon pumps (IABP) and extracorporeal membrane oxygenation (ECMO), offer temporary stabilization but are limited to short‐term use due to risks associated with prolonged blood contact. This research presents a novel proof‐of‐concept soft robotic device designed with the aim of achieving low‐risk, medium‐term counterpulsation therapy. The device employs a nature‐inspired growing mechanism for potentially minimally invasive deployment around the ascending aorta, coupled with hydraulic artificial muscles for aortic compression. It demonstrated a maximum stroke volume of 16.48 ± 0.21 mL (SD, n = 5), outperforming all other non‐pneumatic extra‐aortic devices. In addition, in vitro tests with a mock circulation loop (MCL) show a drop in aortic end‐diastolic pressure by 6.32 mmHg and enhance coronary flow under mild aortic stenosis, which attenuate the device's assistive effect. These findings highlight the device's strong potential for optimization as a promising solution to improve outcomes for hemodynamically unstable HF patients.https://doi.org/10.1002/advs.202412120bioroboticscardiac assistive deviceextra‐aortic conterpulsationhemodynamic stabilizationself‐deployable soft robotic sleevesoft robotics |
| spellingShingle | Adrienne Ji James Davies Phuoc Thien Phan Chi Cong Nguyen Bibhu Sharma Kefan Zhu Emanuele Nicotra Jingjing Wan Hoang‐Phuong Phan Christopher Hayward Nigel H. Lovell Thanh Nho Do Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study Advanced Science biorobotics cardiac assistive device extra‐aortic conterpulsation hemodynamic stabilization self‐deployable soft robotic sleeve soft robotics |
| title | Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study |
| title_full | Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study |
| title_fullStr | Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study |
| title_full_unstemmed | Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study |
| title_short | Development of a Self‐Deploying Extra‐Aortic Compression Device for Medium‐Term Hemodynamic Stabilization: A Feasibility Study |
| title_sort | development of a self deploying extra aortic compression device for medium term hemodynamic stabilization a feasibility study |
| topic | biorobotics cardiac assistive device extra‐aortic conterpulsation hemodynamic stabilization self‐deployable soft robotic sleeve soft robotics |
| url | https://doi.org/10.1002/advs.202412120 |
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