Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years
In 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/274851 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549919526748160 |
|---|---|
| author | Nunzia Giordano Valérie Tikhonoff Paolo Palatini Anna Bascelli Giovanni Boschetti Fabia De Lazzari Carla Grasselli Bortolo Martini Sandro Caffi Antonio Piccoli Alberto Mazza Patrizia Bisiacchi Edoardo Casiglia |
| author_facet | Nunzia Giordano Valérie Tikhonoff Paolo Palatini Anna Bascelli Giovanni Boschetti Fabia De Lazzari Carla Grasselli Bortolo Martini Sandro Caffi Antonio Piccoli Alberto Mazza Patrizia Bisiacchi Edoardo Casiglia |
| author_sort | Nunzia Giordano |
| collection | DOAJ |
| description | In 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 sec (MI-10) (−33%, P=0.03), clock drawing test (CLOX) (−28%, P<0.01), and mini-mental state examination (MMSE) (−6%, P=0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (odds ratio, OR, 0.97, P=0.02; OR 0.98, P<0.005; OR 0.95, P<0.001) and higher pulse blood pressure (BP) (OR 0.97, P=0.02; OR 0.97, P<0.01; and 0.95, P<0.0001). The cognitive reserve index (CRI) was 6% lower in the HT (P=0.03) and was predicted by higher pulse BP (OR 0.82, P<0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. The label of hypertension and higher values of systolic or pulse BP are associated to worse memory and executive functions. Higher diastolic BP, although insufficient to impair cognition, strengthens this association. CRI is predicted by higher systolic BP associated to lower diastolic BP. |
| format | Article |
| id | doaj-art-28aa4b54bf1049b5ba287c9145c02144 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-28aa4b54bf1049b5ba287c9145c021442025-02-03T06:08:11ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/274851274851Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 YearsNunzia Giordano0Valérie Tikhonoff1Paolo Palatini2Anna Bascelli3Giovanni Boschetti4Fabia De Lazzari5Carla Grasselli6Bortolo Martini7Sandro Caffi8Antonio Piccoli9Alberto Mazza10Patrizia Bisiacchi11Edoardo Casiglia12Department of Medicine, University of Padova, Via Giustiniani, 2-VIII Floor, 35128 Padova, ItalyDepartment of Medicine, University of Padova, Via Giustiniani, 2-VIII Floor, 35128 Padova, ItalyDepartment of Medicine, University of Padova, Via Giustiniani, 2-VIII Floor, 35128 Padova, ItalyDepartment of Medicine, University of Padova, Via Giustiniani, 2-VIII Floor, 35128 Padova, ItalyDepartment of Geriatrics, Hospital of Schio, 36015 Schio, ItalyDepartment of Medicine, University of Padova, Via Giustiniani, 2-VIII Floor, 35128 Padova, ItalyDepartment of Geriatrics, Hospital of Schio, 36015 Schio, ItalyDepartment of Cardiology, Hospital of Thiene, 36016 Thiene, ItalyGeneral Direction, Hospital of Verona, 37126 Verona, ItalyNephrology Clinic, University of Padova, 35128 Padova, ItalyDepartment of Medicine, Hospital of Rovigo, 45100 Rovigo, ItalyDepartment of General Psychology, University of Padova, 35128 Padova, ItalyDepartment of Medicine, University of Padova, Via Giustiniani, 2-VIII Floor, 35128 Padova, ItalyIn 288 men and women from general population in a cross-sectional survey, all neuropsychological tests were negatively associated with age; memory and executive function were also positively related with education. The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 sec (MI-10) (−33%, P=0.03), clock drawing test (CLOX) (−28%, P<0.01), and mini-mental state examination (MMSE) (−6%, P=0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (odds ratio, OR, 0.97, P=0.02; OR 0.98, P<0.005; OR 0.95, P<0.001) and higher pulse blood pressure (BP) (OR 0.97, P=0.02; OR 0.97, P<0.01; and 0.95, P<0.0001). The cognitive reserve index (CRI) was 6% lower in the HT (P=0.03) and was predicted by higher pulse BP (OR 0.82, P<0.001). The BP vectors of lower MMSE, MI-10, and CLOX were directed towards higher values of systolic and diastolic BP, that of low CRI towards higher systolic and lower diastolic. The label of hypertension and higher values of systolic or pulse BP are associated to worse memory and executive functions. Higher diastolic BP, although insufficient to impair cognition, strengthens this association. CRI is predicted by higher systolic BP associated to lower diastolic BP.http://dx.doi.org/10.1155/2012/274851 |
| spellingShingle | Nunzia Giordano Valérie Tikhonoff Paolo Palatini Anna Bascelli Giovanni Boschetti Fabia De Lazzari Carla Grasselli Bortolo Martini Sandro Caffi Antonio Piccoli Alberto Mazza Patrizia Bisiacchi Edoardo Casiglia Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years International Journal of Hypertension |
| title | Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years |
| title_full | Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years |
| title_fullStr | Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years |
| title_full_unstemmed | Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years |
| title_short | Cognitive Functions and Cognitive Reserve in Relation to Blood Pressure Components in a Population-Based Cohort Aged 53 to 94 Years |
| title_sort | cognitive functions and cognitive reserve in relation to blood pressure components in a population based cohort aged 53 to 94 years |
| url | http://dx.doi.org/10.1155/2012/274851 |
| work_keys_str_mv | AT nunziagiordano cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT valerietikhonoff cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT paolopalatini cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT annabascelli cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT giovanniboschetti cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT fabiadelazzari cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT carlagrasselli cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT bortolomartini cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT sandrocaffi cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT antoniopiccoli cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT albertomazza cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT patriziabisiacchi cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years AT edoardocasiglia cognitivefunctionsandcognitivereserveinrelationtobloodpressurecomponentsinapopulationbasedcohortaged53to94years |