Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models

Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models

IntroductionPharmacotherapy during lactation often lacks reliable drug safety data, resulting in delayed treatment or early cessation of breastfeeding. In silico tools, such as physiologically-based pharmacokinetic (PBPK) models, can help to bridge this knowledge gap. To increase the accuracy of the...

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Bibliographic Details
Main Authors:	Neel Deferm, Jean Dinh, Amita Pansari, Masoud Jamei, Khaled Abduljalil
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Pharmacology
Subjects:	lactation PBPK postpartum meta-analysis milk breastfeeding
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1517069/full
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