Knowledge-Based Planning and Multi-criteria Optimization Combination with Volumetric Modulated Arc Therapy for Patients with Laryngeal Cancer
Purpose: This study aimed to evaluate the effectiveness of knowledge-based planning (KBP) with additional multi-criteria optimization (MCO) for the volumetric modulated arc therapy (VMAT) of the larynx. Methods: Twenty previously treated VMAT was used to train the KBP model. A manual plan (MP) was c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Medical Physics |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jmp.jmp_192_24 |
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| Summary: | Purpose:
This study aimed to evaluate the effectiveness of knowledge-based planning (KBP) with additional multi-criteria optimization (MCO) for the volumetric modulated arc therapy (VMAT) of the larynx.
Methods:
Twenty previously treated VMAT was used to train the KBP model. A manual plan (MP) was created using 10 patients. The KBP was generated by a single optimization with no planner intervention during the optimization. An additional MCO was applied to KBP (KBP + MCO) to further improve the plan’s quality. All plans were normalized to the planning target volume (PTV) D50% (percentage of the volume receiving 50% of the prescribed dose). The PTV D95%, conformity index (CI), doses to the carotid artery (V10-50 Gy: absolute volume receiving 10–50 Gy), and maximum dose to the spinal cord were calculated for the three planning methods.
Results:
The average PTV D95% for MP, KBP, and KBP + MCO were 90.2%, 92.8%, and 94.1%, respectively. The average CI95% for KBP + MCO was 0.06 and 0.02 higher than that for MP and KBP, respectively. PTV and CI95% were not significantly different between the three planning methods (P > 0.05). KBP + MCO showed that the carotid artery for V10-30 Gy with MP was smaller than that for KBP, and there were no significant differences between V40 Gy and V50 Gy. The maximum dose to the spinal cord did not differ significantly among the three planning methods.
Conclusions:
KBP + MCO could improve dose sparing of the carotid artery while maintaining PTV coverage in laryngeal VMAT. |
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| ISSN: | 0971-6203 1998-3913 |