Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging
Long-term formaldehyde (FA) exposure causes cognitive dysfunction, often associated with metabolic disorders. While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease. However, the effects of GLP on FA-exposed cognitive dysfu...
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Elsevier
2025-04-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325003963 |
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| author | Wen Wang Yuanyuan Sun Renting Cao Wenhui Luo Shujuan Beng Jing Zhang Xiaoqun Wang Can Peng |
| author_facet | Wen Wang Yuanyuan Sun Renting Cao Wenhui Luo Shujuan Beng Jing Zhang Xiaoqun Wang Can Peng |
| author_sort | Wen Wang |
| collection | DOAJ |
| description | Long-term formaldehyde (FA) exposure causes cognitive dysfunction, often associated with metabolic disorders. While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease. However, the effects of GLP on FA-exposed cognitive dysfunction and the regulation of GLP on brain metabolic disturbances caused by FA remain unclear. In our study, we revealed that GLP significantly reversed FA-exposed spatial cognitive deficits in mice by using Morris Water Maze and Histological analysis. Furthermore, desorption electrospray ionization mass spectrometry imaging (DESI-MSI) found that exposure of FA can caused dysregulated expression of 35 metabolites. Following GLP treatment, there was a significant restoration of the imbalance of choline and acetylcholine, carnitine and acetylcarnitine, and spermidine and spermine, which were all involved in choline metabolism, carnitine metabolism, and polyamine metabolism. Our results suggested that GLP alleviated FA-exposed cognitive dysfunction, likely through modulation of metabolic pathways, providing a potential therapeutic approach for FA-related cognitive dysfunction. |
| format | Article |
| id | doaj-art-28a26b2aacbc496388976e1a57ee1e07 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-28a26b2aacbc496388976e1a57ee1e072025-08-20T03:09:23ZengElsevierEcotoxicology and Environmental Safety0147-65132025-04-0129411806010.1016/j.ecoenv.2025.118060Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imagingWen Wang0Yuanyuan Sun1Renting Cao2Wenhui Luo3Shujuan Beng4Jing Zhang5Xiaoqun Wang6Can Peng7Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaCenter for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaCenter for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, ChinaCenter for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Corresponding authors at: Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Corresponding author.Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Generic Technology Research center for Anhui TCM Industry, Anhui University of Chinese Medicine, Hefei 230012, China; Rural Revitalization Collaborative Technical Service Center of Anhui Province, Anhui University of Chinese Medicine, Hefei 230012, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Anhui University of Chinese Medicine, Hefei 230012, China; Corresponding authors at: Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China.Long-term formaldehyde (FA) exposure causes cognitive dysfunction, often associated with metabolic disorders. While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease. However, the effects of GLP on FA-exposed cognitive dysfunction and the regulation of GLP on brain metabolic disturbances caused by FA remain unclear. In our study, we revealed that GLP significantly reversed FA-exposed spatial cognitive deficits in mice by using Morris Water Maze and Histological analysis. Furthermore, desorption electrospray ionization mass spectrometry imaging (DESI-MSI) found that exposure of FA can caused dysregulated expression of 35 metabolites. Following GLP treatment, there was a significant restoration of the imbalance of choline and acetylcholine, carnitine and acetylcarnitine, and spermidine and spermine, which were all involved in choline metabolism, carnitine metabolism, and polyamine metabolism. Our results suggested that GLP alleviated FA-exposed cognitive dysfunction, likely through modulation of metabolic pathways, providing a potential therapeutic approach for FA-related cognitive dysfunction.http://www.sciencedirect.com/science/article/pii/S0147651325003963Ganoderma lucidum polysaccharides Formaldehyde Cognitive Dysfunction DESI-MSI Metabolites |
| spellingShingle | Wen Wang Yuanyuan Sun Renting Cao Wenhui Luo Shujuan Beng Jing Zhang Xiaoqun Wang Can Peng Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging Ecotoxicology and Environmental Safety Ganoderma lucidum polysaccharides Formaldehyde Cognitive Dysfunction DESI-MSI Metabolites |
| title | Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging |
| title_full | Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging |
| title_fullStr | Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging |
| title_full_unstemmed | Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging |
| title_short | Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging |
| title_sort | illustrate the metabolic regulatory effects of ganoderma lucidum polysaccharides on cognitive dysfunction in formaldehyde exposed mouse brain by mass spectrometry imaging |
| topic | Ganoderma lucidum polysaccharides Formaldehyde Cognitive Dysfunction DESI-MSI Metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325003963 |
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