Adult-onset hypothyroidism induces granulosa cell apoptosis and affects ovarian follicle development in rats

Adult-onset hypothyroidism induces granulosa cell apoptosis and affects ovarian follicle development in rats

IntroductionHypothyroidism is a common endocrine disorder in women, which could lead to ovulation disorders and infertility, however, the effects of adult-onset hypothyroidism on ovarian development and gene expression characteristics need further study.MethodsHere we conducted an adult-onset hypoth...

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Bibliographic Details
Main Authors: Shuyue Li, Lina Zhang, Wanqiong Li, Jiaying Qin, Lingbin Qi, Xi Xiao, Zhigang Xue, Jinfeng Xue, Yazhong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adult-onset hypothyroidism
granulosa cell
apoptosis
oocyte
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1610694/full
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