Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice

Activity-dependent degradation of Kv4.2 contributes to synaptic plasticity and behavior in Angelman syndrome model mice

Summary: Angelman syndrome (AS) is a severe neurological disorder characterized by intellectual disability, absence of speech, spontaneous seizure, and motor dysfunction. The absence of functional maternally derived UBE3A protein is considered the primary cause of AS, yet the downstream signaling pa...

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Bibliographic Details
Main Authors: Jia-Hua Hu, Cole Malloy, Ying Liu, Jung M. Park, Ashley Pratt, Meghyn Welch, Jonathan G. Murphy, Daniel Abebe, Rose-Marie Karlsson, Heather A. Cameron, Dax A. Hoffman
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003547
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