Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141)
Abstract Genetically modified cotton COT102 was developed to confer resistance against several lepidopteran species. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the differences in the agronomic‐phenotypic and co...
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Wiley
2023-06-01
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| Online Access: | https://doi.org/10.2903/j.efsa.2023.8031 |
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| author | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Hanspeter Naegeli Francisco Javier Moreno Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Giacomo De Sanctis Antonio Fernández Andrea Gennaro José Ángel Gómez Ruiz Tilemachos Goumperis Dafni Maria Kagli Paolo Lenzi Aleksandra Lewandowska Ana M Camargo Franco Maria Neri Nikoletta Papadopoulou Tommaso Raffaello |
| author_facet | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Hanspeter Naegeli Francisco Javier Moreno Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Giacomo De Sanctis Antonio Fernández Andrea Gennaro José Ángel Gómez Ruiz Tilemachos Goumperis Dafni Maria Kagli Paolo Lenzi Aleksandra Lewandowska Ana M Camargo Franco Maria Neri Nikoletta Papadopoulou Tommaso Raffaello |
| author_sort | EFSA Panel on Genetically Modified Organisms (GMO) |
| collection | DOAJ |
| description | Abstract Genetically modified cotton COT102 was developed to confer resistance against several lepidopteran species. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the differences in the agronomic‐phenotypic and compositional characteristics between cotton COT102 and its non‐GM comparator needs further assessment, except for levels of acid detergent fibre, which do not raise safety or nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Vip3Aa19 and APH4 proteins as expressed in cotton COT102 and finds no evidence that the genetic modification would change the overall allergenicity of cotton COT102. In the context of this application, the consumption of food and feed from cotton COT102 does not represent a nutritional concern for humans and animals. The GMO Panel concludes that cotton COT102 is as safe as the non‐GM comparator and non‐GM cotton varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable cotton COT102 seeds into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of cotton COT102. The GMO Panel concludes that cotton COT102 is as safe as its non‐GM comparator and the tested non‐GM cotton varieties with respect to potential effects on human and animal health and the environment. |
| format | Article |
| id | doaj-art-2893eef1456b403692fe753cdfdf0acd |
| institution | DOAJ |
| issn | 1831-4732 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wiley |
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| series | EFSA Journal |
| spelling | doaj-art-2893eef1456b403692fe753cdfdf0acd2025-08-20T03:09:02ZengWileyEFSA Journal1831-47322023-06-01216n/an/a10.2903/j.efsa.2023.8031Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141)EFSA Panel on Genetically Modified Organisms (GMO)Ewen MullinsJean‐Louis BressonTamas DalmayIan Crawford DewhurstMichelle M EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneGiacomo De SanctisAntonio FernándezAndrea GennaroJosé Ángel Gómez RuizTilemachos GoumperisDafni Maria KagliPaolo LenziAleksandra LewandowskaAna M CamargoFranco Maria NeriNikoletta PapadopoulouTommaso RaffaelloAbstract Genetically modified cotton COT102 was developed to confer resistance against several lepidopteran species. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the differences in the agronomic‐phenotypic and compositional characteristics between cotton COT102 and its non‐GM comparator needs further assessment, except for levels of acid detergent fibre, which do not raise safety or nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Vip3Aa19 and APH4 proteins as expressed in cotton COT102 and finds no evidence that the genetic modification would change the overall allergenicity of cotton COT102. In the context of this application, the consumption of food and feed from cotton COT102 does not represent a nutritional concern for humans and animals. The GMO Panel concludes that cotton COT102 is as safe as the non‐GM comparator and non‐GM cotton varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable cotton COT102 seeds into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of cotton COT102. The GMO Panel concludes that cotton COT102 is as safe as its non‐GM comparator and the tested non‐GM cotton varieties with respect to potential effects on human and animal health and the environment.https://doi.org/10.2903/j.efsa.2023.8031GMgenetic engineeringcotton (Gossypium hirsutum)COT102Vip3Aa19APH4 |
| spellingShingle | EFSA Panel on Genetically Modified Organisms (GMO) Ewen Mullins Jean‐Louis Bresson Tamas Dalmay Ian Crawford Dewhurst Michelle M Epstein Leslie George Firbank Philippe Guerche Jan Hejatko Hanspeter Naegeli Francisco Javier Moreno Fabien Nogué Nils Rostoks Jose Juan Sánchez Serrano Giovanni Savoini Eve Veromann Fabio Veronesi Michele Ardizzone Giacomo De Sanctis Antonio Fernández Andrea Gennaro José Ángel Gómez Ruiz Tilemachos Goumperis Dafni Maria Kagli Paolo Lenzi Aleksandra Lewandowska Ana M Camargo Franco Maria Neri Nikoletta Papadopoulou Tommaso Raffaello Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141) EFSA Journal GM genetic engineering cotton (Gossypium hirsutum) COT102 Vip3Aa19 APH4 |
| title | Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141) |
| title_full | Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141) |
| title_fullStr | Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141) |
| title_full_unstemmed | Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141) |
| title_short | Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141) |
| title_sort | assessment of genetically modified cotton cot102 for food and feed uses under regulation ec no 1829 2003 application efsa gmo de 2017 141 |
| topic | GM genetic engineering cotton (Gossypium hirsutum) COT102 Vip3Aa19 APH4 |
| url | https://doi.org/10.2903/j.efsa.2023.8031 |
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