Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin

Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin

IntroductionFerroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation of lipid peroxides on cellular membranes. It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition o...

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Main Authors: Ziwei Yang, Tixin Han, Ruibin Yang, Yinuo Zhang, Yifei Qin, Jialu Hou, Fei Huo, Zhuan Feng, Yaxin Ding, Jiali Yang, Gang Zhou, Shijie Wang, Xiaohang Xie, Peng Lin, Zhi-Nan Chen, Jiao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
ferroptosis
NRF2
NQO1
SLC7A11
prognostic model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531874/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531874/full

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