Non-canonical hemoglobin: An updated review on its ubiquitous expression
Hemoglobin, once thought to be exclusive to erythrocytes, has been identified to be expressed in various cell types over the past several decades. While hemoglobin's function within erythrocytes is primarily characterized as a gaseous transport molecule, its function within non-erythrocyte cell...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Redox Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231725001156 |
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| author | Emily C. Reed Jacob D. Kim Adam J. Case |
| author_facet | Emily C. Reed Jacob D. Kim Adam J. Case |
| author_sort | Emily C. Reed |
| collection | DOAJ |
| description | Hemoglobin, once thought to be exclusive to erythrocytes, has been identified to be expressed in various cell types over the past several decades. While hemoglobin's function within erythrocytes is primarily characterized as a gaseous transport molecule, its function within non-erythrocyte cells varies among different cell types, and in many cases, remains to be fully elucidated. Despite this variability, hemoglobin expression seems to broadly function as a redox modulator, whether it is involved in the hypoxic response, mitochondrial function, antioxidant balance or, like in erythrocytes, gas transport. This review provides an updated summary of the most recent discoveries of hemoglobin in non-erythrocyte cells. While discussing the function and regulation of this ubiquitous protein, we additionally compare these cell-specific details to identify commonalities throughout the diverse group of hemoglobin-expressing cells. Lastly, we discuss potential implications of non-canonical hemoglobin in various disease states such neurodegeneration, autoimmune disorders, psychological trauma, and hemoglobinopathies, while providing future directions for hemoglobin research. |
| format | Article |
| id | doaj-art-287eb5db52154db3bc8be790616d805c |
| institution | DOAJ |
| issn | 2213-2317 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj-art-287eb5db52154db3bc8be790616d805c2025-08-20T03:14:52ZengElsevierRedox Biology2213-23172025-05-018210360210.1016/j.redox.2025.103602Non-canonical hemoglobin: An updated review on its ubiquitous expressionEmily C. Reed0Jacob D. Kim1Adam J. Case2Department of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States; Department of Medical Physiology, Texas A&M University, Bryan, TX, United StatesProsper High School, Prosper, TX, United StatesDepartment of Psychiatry and Behavioral Sciences, Texas A&M University, Bryan, TX, United States; Department of Medical Physiology, Texas A&M University, Bryan, TX, United States; Corresponding author. Department of Psychiatry and Behavioral Sciences, Department of Medical Physiology, 8447 John Sharp Pkwy, MREB2 3414, Bryan, TX 77807, United States. acase@tamu.eduHemoglobin, once thought to be exclusive to erythrocytes, has been identified to be expressed in various cell types over the past several decades. While hemoglobin's function within erythrocytes is primarily characterized as a gaseous transport molecule, its function within non-erythrocyte cells varies among different cell types, and in many cases, remains to be fully elucidated. Despite this variability, hemoglobin expression seems to broadly function as a redox modulator, whether it is involved in the hypoxic response, mitochondrial function, antioxidant balance or, like in erythrocytes, gas transport. This review provides an updated summary of the most recent discoveries of hemoglobin in non-erythrocyte cells. While discussing the function and regulation of this ubiquitous protein, we additionally compare these cell-specific details to identify commonalities throughout the diverse group of hemoglobin-expressing cells. Lastly, we discuss potential implications of non-canonical hemoglobin in various disease states such neurodegeneration, autoimmune disorders, psychological trauma, and hemoglobinopathies, while providing future directions for hemoglobin research.http://www.sciencedirect.com/science/article/pii/S2213231725001156HemoglobinHbαHbβReactive oxygen speciesMitochondriaRedox |
| spellingShingle | Emily C. Reed Jacob D. Kim Adam J. Case Non-canonical hemoglobin: An updated review on its ubiquitous expression Redox Biology Hemoglobin Hbα Hbβ Reactive oxygen species Mitochondria Redox |
| title | Non-canonical hemoglobin: An updated review on its ubiquitous expression |
| title_full | Non-canonical hemoglobin: An updated review on its ubiquitous expression |
| title_fullStr | Non-canonical hemoglobin: An updated review on its ubiquitous expression |
| title_full_unstemmed | Non-canonical hemoglobin: An updated review on its ubiquitous expression |
| title_short | Non-canonical hemoglobin: An updated review on its ubiquitous expression |
| title_sort | non canonical hemoglobin an updated review on its ubiquitous expression |
| topic | Hemoglobin Hbα Hbβ Reactive oxygen species Mitochondria Redox |
| url | http://www.sciencedirect.com/science/article/pii/S2213231725001156 |
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