Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro
Papillary thyroid carcinoma (PTC) is the main type of malignant tumor of the thyroid gland in adults. Huaier, a traditional Chinese medicinal agent, has demonstrated antitumor efficacy across diverse malignant neoplasms. However, the specific impact of huaier in PTC remains insufficiently elucidated...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-05-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354251339073 |
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| author | Fa-Zhan Xu MS Lu-Lu Zheng MS Jia-Bo Qin MS Yi-Xuan Li MS Ke-Hao Chen MS Ling-Hui Dai MS Qiao-Ling Zhu MS Jian-Feng Sang MD |
| author_facet | Fa-Zhan Xu MS Lu-Lu Zheng MS Jia-Bo Qin MS Yi-Xuan Li MS Ke-Hao Chen MS Ling-Hui Dai MS Qiao-Ling Zhu MS Jian-Feng Sang MD |
| author_sort | Fa-Zhan Xu MS |
| collection | DOAJ |
| description | Papillary thyroid carcinoma (PTC) is the main type of malignant tumor of the thyroid gland in adults. Huaier, a traditional Chinese medicinal agent, has demonstrated antitumor efficacy across diverse malignant neoplasms. However, the specific impact of huaier in PTC remains insufficiently elucidated. In this study, we explored the function of huaier in PTC. We treated a PTC cell line (TPC-1) with varying concentration gradients of huaier and we observed that huaier effectively inhibited the proliferation of TPC-1 cells with an IC50 of 2.538 mg/ml. Huaier also modulated the cell cycle of the TPC-1 cell line, and induced apoptosis in TPC-1. Huaier treatment inhibited migration and invasion of TPC-1 cells. Further studies showed that in TPC-1 cells, huaier treatment inhibited the expression of the MAPK and HSP27/STAT3/AKT signaling pathway. We subsequently demonstrated in a nude mouse model that huaier treatment inhibited the progression of PTC tumors. In summary, our data suggest that huaier can inhibit the proliferation, migration, and invasion of PTC cells in vitro and the progression of PTC tumors in vivo, and that this effect may be related to the MAPK and HSP27/STAT3/AKT signaling pathway; therefore, huaier extract is expected to be a new direction for the treatment of PTC. |
| format | Article |
| id | doaj-art-287d8565dbc24528b67a94a46bf7b30b |
| institution | Kabale University |
| issn | 1552-695X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj-art-287d8565dbc24528b67a94a46bf7b30b2025-08-20T03:52:47ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2025-05-012410.1177/15347354251339073Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitroFa-Zhan Xu MS0Lu-Lu Zheng MS1Jia-Bo Qin MS2Yi-Xuan Li MS3Ke-Hao Chen MS4Ling-Hui Dai MS5Qiao-Ling Zhu MS6Jian-Feng Sang MD7Division of Thyroid Surgery, Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, ChinaDivision of Thyroid Surgery, Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, ChinaDivision of Thyroid Surgery, Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, ChinaMedical School of Nanjing University, Nanjing, ChinaDivision of Thyroid Surgery, Department of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, ChinaMedical School of Nanjing University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDivision of Thyroid Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaPapillary thyroid carcinoma (PTC) is the main type of malignant tumor of the thyroid gland in adults. Huaier, a traditional Chinese medicinal agent, has demonstrated antitumor efficacy across diverse malignant neoplasms. However, the specific impact of huaier in PTC remains insufficiently elucidated. In this study, we explored the function of huaier in PTC. We treated a PTC cell line (TPC-1) with varying concentration gradients of huaier and we observed that huaier effectively inhibited the proliferation of TPC-1 cells with an IC50 of 2.538 mg/ml. Huaier also modulated the cell cycle of the TPC-1 cell line, and induced apoptosis in TPC-1. Huaier treatment inhibited migration and invasion of TPC-1 cells. Further studies showed that in TPC-1 cells, huaier treatment inhibited the expression of the MAPK and HSP27/STAT3/AKT signaling pathway. We subsequently demonstrated in a nude mouse model that huaier treatment inhibited the progression of PTC tumors. In summary, our data suggest that huaier can inhibit the proliferation, migration, and invasion of PTC cells in vitro and the progression of PTC tumors in vivo, and that this effect may be related to the MAPK and HSP27/STAT3/AKT signaling pathway; therefore, huaier extract is expected to be a new direction for the treatment of PTC.https://doi.org/10.1177/15347354251339073 |
| spellingShingle | Fa-Zhan Xu MS Lu-Lu Zheng MS Jia-Bo Qin MS Yi-Xuan Li MS Ke-Hao Chen MS Ling-Hui Dai MS Qiao-Ling Zhu MS Jian-Feng Sang MD Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro Integrative Cancer Therapies |
| title | Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro |
| title_full | Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro |
| title_fullStr | Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro |
| title_full_unstemmed | Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro |
| title_short | Pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro |
| title_sort | pharmacodynamics of huaier aqueous extract against papillary thyroid carcinoma in vivo and in vitro |
| url | https://doi.org/10.1177/15347354251339073 |
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