Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction

Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction

Abstract Giant congenital melanocytic nevus (GCMN) is a RAS/RAF mutation-driven syndrome characterized by extensive melanocytic lesions, posing psychological challenges and a lifelong risk of malignancy. Existing treatments like surgical resection and laser therapy fail to fully remove lesions, and...

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Main Authors: Boxuan Wei, Qingxiong Yu, Jiamin Jin, Danli Zhu, Bohan Lai, Jieyu Gu, Ran Yang, Huailiang Huang, Hongzhan Lin, Liang Zhang, Tao Zan, Feng Xie, Kang Zhang, Qingfeng Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02247-2
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https://doi.org/10.1038/s41392-025-02247-2

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