Neuronal activation in the axolotl brain promotes tail regeneration
Abstract The axolotl retains a remarkable capacity for regenerative repair and is one of the few vertebrate species capable of regenerating its brain and spinal cord after injury. To date, studies investigating axolotl spinal cord regeneration have placed particular emphasis on understanding how cel...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Regenerative Medicine |
| Online Access: | https://doi.org/10.1038/s41536-025-00413-2 |
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| author | SE Walker K. Yu S. Burgess K. Echeverri |
| author_facet | SE Walker K. Yu S. Burgess K. Echeverri |
| author_sort | SE Walker |
| collection | DOAJ |
| description | Abstract The axolotl retains a remarkable capacity for regenerative repair and is one of the few vertebrate species capable of regenerating its brain and spinal cord after injury. To date, studies investigating axolotl spinal cord regeneration have placed particular emphasis on understanding how cells immediately adjacent to the injury site respond to damage to promote regenerative repair. How neurons outside of this immediate injury site respond to an injury remains unknown. Here, we identify a population of dpErk+/etv1 + glutamatergic neurons in the axolotl telencephalon that are activated in response to injury and are essential for tail regeneration. Furthermore, these neurons project to the hypothalamus where they upregulate the neuropeptide neurotensin in response to injury. Together, these findings identify a unique population of neurons in the axolotl brain whose activation is necessary for successful tail regeneration, and sheds light on how neurons outside of the immediate injury site respond to an injury. |
| format | Article |
| id | doaj-art-286a4ee076324b00abe34d719e65bd0b |
| institution | DOAJ |
| issn | 2057-3995 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Regenerative Medicine |
| spelling | doaj-art-286a4ee076324b00abe34d719e65bd0b2025-08-20T03:09:34ZengNature Portfolionpj Regenerative Medicine2057-39952025-05-0110111710.1038/s41536-025-00413-2Neuronal activation in the axolotl brain promotes tail regenerationSE Walker0K. Yu1S. Burgess2K. Echeverri3Marine Biological Laboratory, Eugene Bell Center for Regenerative BiologyTranslational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of HealthTranslational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of HealthMarine Biological Laboratory, Eugene Bell Center for Regenerative BiologyAbstract The axolotl retains a remarkable capacity for regenerative repair and is one of the few vertebrate species capable of regenerating its brain and spinal cord after injury. To date, studies investigating axolotl spinal cord regeneration have placed particular emphasis on understanding how cells immediately adjacent to the injury site respond to damage to promote regenerative repair. How neurons outside of this immediate injury site respond to an injury remains unknown. Here, we identify a population of dpErk+/etv1 + glutamatergic neurons in the axolotl telencephalon that are activated in response to injury and are essential for tail regeneration. Furthermore, these neurons project to the hypothalamus where they upregulate the neuropeptide neurotensin in response to injury. Together, these findings identify a unique population of neurons in the axolotl brain whose activation is necessary for successful tail regeneration, and sheds light on how neurons outside of the immediate injury site respond to an injury.https://doi.org/10.1038/s41536-025-00413-2 |
| spellingShingle | SE Walker K. Yu S. Burgess K. Echeverri Neuronal activation in the axolotl brain promotes tail regeneration npj Regenerative Medicine |
| title | Neuronal activation in the axolotl brain promotes tail regeneration |
| title_full | Neuronal activation in the axolotl brain promotes tail regeneration |
| title_fullStr | Neuronal activation in the axolotl brain promotes tail regeneration |
| title_full_unstemmed | Neuronal activation in the axolotl brain promotes tail regeneration |
| title_short | Neuronal activation in the axolotl brain promotes tail regeneration |
| title_sort | neuronal activation in the axolotl brain promotes tail regeneration |
| url | https://doi.org/10.1038/s41536-025-00413-2 |
| work_keys_str_mv | AT sewalker neuronalactivationintheaxolotlbrainpromotestailregeneration AT kyu neuronalactivationintheaxolotlbrainpromotestailregeneration AT sburgess neuronalactivationintheaxolotlbrainpromotestailregeneration AT kecheverri neuronalactivationintheaxolotlbrainpromotestailregeneration |