Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo
Capsosiphon fulvescens has potential benefits for functionality. However, research on its impact on gut health is limited. In this study, the therapeutic efficacy of Capsosiphon fulvescens water extract (CFW) was investigated, with its intestinal health benefits confirmed in Caco-2 cell and mouse mo...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624005668 |
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| author | Yu Rim Kim Soo-yeon Park Ji Yeon Kim |
| author_facet | Yu Rim Kim Soo-yeon Park Ji Yeon Kim |
| author_sort | Yu Rim Kim |
| collection | DOAJ |
| description | Capsosiphon fulvescens has potential benefits for functionality. However, research on its impact on gut health is limited. In this study, the therapeutic efficacy of Capsosiphon fulvescens water extract (CFW) was investigated, with its intestinal health benefits confirmed in Caco-2 cell and mouse models. In the animal study, 32 male C57BL/6 mice were divided into control, DSS, and CFW treatment groups and treated for 28 days, with DSS given ad libitum in 7 days. Significant improvements in various biomarkers related to intestinal barrier function, including increased transepithelial electrical resistance values and reduced permeability, were observed in vitro model. Moreover, the administration of CFW was associated with improved histological scores and improved levels of TJ proteins and cytokines. The therapeutic efficacy of CFW is believed to be associated with the bioactive compounds found in the extract. The findings here highlight the promising therapeutic potential of CFW for managing inflammatory bowel disease. |
| format | Article |
| id | doaj-art-2869f105637e4b74969104194ac53622 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-2869f105637e4b74969104194ac536222024-12-14T06:30:10ZengElsevierJournal of Functional Foods1756-46462024-12-01123106563Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivoYu Rim Kim0Soo-yeon Park1Ji Yeon Kim2Department of Food Science and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Republic of KoreaDepartment of Food Science and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Republic of KoreaCorresponding author.; Department of Food Science and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Republic of KoreaCapsosiphon fulvescens has potential benefits for functionality. However, research on its impact on gut health is limited. In this study, the therapeutic efficacy of Capsosiphon fulvescens water extract (CFW) was investigated, with its intestinal health benefits confirmed in Caco-2 cell and mouse models. In the animal study, 32 male C57BL/6 mice were divided into control, DSS, and CFW treatment groups and treated for 28 days, with DSS given ad libitum in 7 days. Significant improvements in various biomarkers related to intestinal barrier function, including increased transepithelial electrical resistance values and reduced permeability, were observed in vitro model. Moreover, the administration of CFW was associated with improved histological scores and improved levels of TJ proteins and cytokines. The therapeutic efficacy of CFW is believed to be associated with the bioactive compounds found in the extract. The findings here highlight the promising therapeutic potential of CFW for managing inflammatory bowel disease.http://www.sciencedirect.com/science/article/pii/S1756464624005668SeaweedAlgaeCapsosiphon fulvescensIntestinal barrier functionInflammatory bowel diseasesDextran sulfate sodium |
| spellingShingle | Yu Rim Kim Soo-yeon Park Ji Yeon Kim Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo Journal of Functional Foods Seaweed Algae Capsosiphon fulvescens Intestinal barrier function Inflammatory bowel diseases Dextran sulfate sodium |
| title | Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo |
| title_full | Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo |
| title_fullStr | Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo |
| title_full_unstemmed | Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo |
| title_short | Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo |
| title_sort | comprehensive evaluation of capsosiphon fulvescens water extract assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo |
| topic | Seaweed Algae Capsosiphon fulvescens Intestinal barrier function Inflammatory bowel diseases Dextran sulfate sodium |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624005668 |
| work_keys_str_mv | AT yurimkim comprehensiveevaluationofcapsosiphonfulvescenswaterextractassessingitseffectsonintestinalbarrierintegrityandinflammationinvitroandinvivo AT sooyeonpark comprehensiveevaluationofcapsosiphonfulvescenswaterextractassessingitseffectsonintestinalbarrierintegrityandinflammationinvitroandinvivo AT jiyeonkim comprehensiveevaluationofcapsosiphonfulvescenswaterextractassessingitseffectsonintestinalbarrierintegrityandinflammationinvitroandinvivo |