Repeated corneal crosslinking for progressive keratoconus: efficiency and safety

Corneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical...

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Main Authors: Eleftherios Chatzimichail, Georgios Chondrozoumakis, Farideh Doroodgar, Efstathios Vounotrypidis, Georgios D. Panos, Nicolas Feltgen, Zisis Gatzioufas
Format: Article
Language:English
Published: SAGE Publishing 2025-06-01
Series:Therapeutic Advances in Ophthalmology
Online Access:https://doi.org/10.1177/25158414251350071
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author Eleftherios Chatzimichail
Georgios Chondrozoumakis
Farideh Doroodgar
Efstathios Vounotrypidis
Georgios D. Panos
Nicolas Feltgen
Zisis Gatzioufas
author_facet Eleftherios Chatzimichail
Georgios Chondrozoumakis
Farideh Doroodgar
Efstathios Vounotrypidis
Georgios D. Panos
Nicolas Feltgen
Zisis Gatzioufas
author_sort Eleftherios Chatzimichail
collection DOAJ
description Corneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical outcomes and safety profile. Progression of keratoconus after primary CXL is very rare, but it has been reported in the literature. This review summarises the existing data on repeated CXL after primary failure, emphasising on clinical efficacy and safety.
format Article
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institution Kabale University
issn 2515-8414
language English
publishDate 2025-06-01
publisher SAGE Publishing
record_format Article
series Therapeutic Advances in Ophthalmology
spelling doaj-art-286755af43584043a005a85c6aa0f9072025-08-20T03:32:11ZengSAGE PublishingTherapeutic Advances in Ophthalmology2515-84142025-06-011710.1177/25158414251350071Repeated corneal crosslinking for progressive keratoconus: efficiency and safetyEleftherios ChatzimichailGeorgios ChondrozoumakisFarideh DoroodgarEfstathios VounotrypidisGeorgios D. PanosNicolas FeltgenZisis GatzioufasCorneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical outcomes and safety profile. Progression of keratoconus after primary CXL is very rare, but it has been reported in the literature. This review summarises the existing data on repeated CXL after primary failure, emphasising on clinical efficacy and safety.https://doi.org/10.1177/25158414251350071
spellingShingle Eleftherios Chatzimichail
Georgios Chondrozoumakis
Farideh Doroodgar
Efstathios Vounotrypidis
Georgios D. Panos
Nicolas Feltgen
Zisis Gatzioufas
Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
Therapeutic Advances in Ophthalmology
title Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
title_full Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
title_fullStr Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
title_full_unstemmed Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
title_short Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
title_sort repeated corneal crosslinking for progressive keratoconus efficiency and safety
url https://doi.org/10.1177/25158414251350071
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