Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria
Biotransformation of organic compounds through bioconversion could be an effective strategy for improving the gut microbiota and sarcopenia. The effects of bioconversion product (WDG) of wine grape seed flour (G) extract and whey (W) with kefir lactic acid bacteria (D) were evaluated in C2C12 myobla...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Future Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266683352500022X |
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| author | Kun-Ho Seo Eseul Kim Hyunsook Kim |
| author_facet | Kun-Ho Seo Eseul Kim Hyunsook Kim |
| author_sort | Kun-Ho Seo |
| collection | DOAJ |
| description | Biotransformation of organic compounds through bioconversion could be an effective strategy for improving the gut microbiota and sarcopenia. The effects of bioconversion product (WDG) of wine grape seed flour (G) extract and whey (W) with kefir lactic acid bacteria (D) were evaluated in C2C12 myoblasts and a hindlimb-immobilized mouse model. WDG significantly restored palmitate-induced decreases in myotube length and diameter. C57BL/6 J mice were hindlimb-immobilized for 2 weeks and fed a high-fat (HF) diet with G, W, WG, WD (W + D), or WDG for an additional 5 weeks. Supplementation with WDG synergistically ameliorated immobilization-induced sarcopenia by restoring grip strength, muscle weight, and the expression of genes related to muscle growth markers. Notably, WDG significantly modulated the abundance of butyrate-producing and intestinal barrier function-related gut bacteria, which were significantly and positively correlated with holding impulse and muscle growth markers. In conclusion, the bioconversion of G and W with D may be a useful strategy to establish healthy gut microbiota and prevent sarcopenia. |
| format | Article |
| id | doaj-art-28673165e7c2438d9d34562267d80570 |
| institution | Kabale University |
| issn | 2666-8335 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Future Foods |
| spelling | doaj-art-28673165e7c2438d9d34562267d805702025-02-10T04:35:01ZengElsevierFuture Foods2666-83352025-06-0111100559Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteriaKun-Ho Seo0Eseul Kim1Hyunsook Kim2Center for One Health, Department of Veterinary Public Health, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South KoreaDepartment of Food & Nutrition, College of Human Ecology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South KoreaDepartment of Food & Nutrition, College of Human Ecology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea; Corresponding author at: Department of Food and Nutrition, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea.Biotransformation of organic compounds through bioconversion could be an effective strategy for improving the gut microbiota and sarcopenia. The effects of bioconversion product (WDG) of wine grape seed flour (G) extract and whey (W) with kefir lactic acid bacteria (D) were evaluated in C2C12 myoblasts and a hindlimb-immobilized mouse model. WDG significantly restored palmitate-induced decreases in myotube length and diameter. C57BL/6 J mice were hindlimb-immobilized for 2 weeks and fed a high-fat (HF) diet with G, W, WG, WD (W + D), or WDG for an additional 5 weeks. Supplementation with WDG synergistically ameliorated immobilization-induced sarcopenia by restoring grip strength, muscle weight, and the expression of genes related to muscle growth markers. Notably, WDG significantly modulated the abundance of butyrate-producing and intestinal barrier function-related gut bacteria, which were significantly and positively correlated with holding impulse and muscle growth markers. In conclusion, the bioconversion of G and W with D may be a useful strategy to establish healthy gut microbiota and prevent sarcopenia.http://www.sciencedirect.com/science/article/pii/S266683352500022XBioconversionKefir lactic acid bacteriaGut microbiotaSarcopeniaWine grape seed |
| spellingShingle | Kun-Ho Seo Eseul Kim Hyunsook Kim Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria Future Foods Bioconversion Kefir lactic acid bacteria Gut microbiota Sarcopenia Wine grape seed |
| title | Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria |
| title_full | Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria |
| title_fullStr | Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria |
| title_full_unstemmed | Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria |
| title_short | Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria |
| title_sort | synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria |
| topic | Bioconversion Kefir lactic acid bacteria Gut microbiota Sarcopenia Wine grape seed |
| url | http://www.sciencedirect.com/science/article/pii/S266683352500022X |
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