A Parent–Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling

A Parent–Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling

<b>Background</b>: Glucuronide recycling in the gut and liver profoundly affects the systemic and/or local exposure of drugs and their glucuronide metabolites, impacting both clinical efficacy and toxicity. This recycling also alters drug exposure in the colon, making it critical to esta...

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Bibliographic Details
Main Authors: Bhargavi Srija Ramisetty, Rashim Singh, Ming Hu, Michael Zhuo Wang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
PBPK
gut microbiome
enterohepatic circulation
glucuronide recycling
drug transporters
colon targeting
Online Access:https://www.mdpi.com/1999-4923/17/7/814
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