Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy

Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy

Abstract Incomplete tumor removal after microwave ablation (MWA), a widely used hyperthermia-based therapy, can result in tumor recurrence. Herein, attenuated Salmonella typhimurium VNP20009 is engineered to release interleukin-15&interleukin-15-receptor-alpha (IL-15&IL-15Rα) in response to...

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Main Authors: Yumin Wu, Bo Liu, Yifan Yan, Chuntao Gong, Kaiwei Wang, Nanhui Liu, Yujie Zhu, Maoyi Li, Chunjie Wang, Yizhe Yang, Liangzhu Feng, Zhuang Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54883-x
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