Small but Mighty: Nanobodies in the Fight Against Infectious Diseases
Infectious diseases, caused by pathogenic microorganisms and capable of spreading, pose a significant threat to global public health. Developing efficient and cost-effective techniques for treating infectious diseases is crucial in curbing their progression and reducing patients’ morbidity and morta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/5/610 |
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| author | Wenning Jiang Chundong Huang Serge Muyldermans Lingyun Jia |
| author_facet | Wenning Jiang Chundong Huang Serge Muyldermans Lingyun Jia |
| author_sort | Wenning Jiang |
| collection | DOAJ |
| description | Infectious diseases, caused by pathogenic microorganisms and capable of spreading, pose a significant threat to global public health. Developing efficient and cost-effective techniques for treating infectious diseases is crucial in curbing their progression and reducing patients’ morbidity and mortality. Nanobodies (Nbs), a novel class of affinity reagents derived from unique heavy chain-only antibodies in camelids, represent the smallest intact and fully functional antigen-binding fragments. Compared with conventional antibodies and their antigen binding fragments, Nbs offer numerous advantages, including high affinity, exceptional target specificity, cost-effective production, easy accessibility, and robust stability, demonstrating immense potential in infectious disease treatment. This review introduces Nbs and focuses on discussing their mechanisms and intervention strategies in the treatment of viral and bacterial infections. |
| format | Article |
| id | doaj-art-285fb4e4b9944e01ab1668f153c8642a |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-285fb4e4b9944e01ab1668f153c8642a2025-08-20T02:33:40ZengMDPI AGBiomolecules2218-273X2025-04-0115561010.3390/biom15050610Small but Mighty: Nanobodies in the Fight Against Infectious DiseasesWenning Jiang0Chundong Huang1Serge Muyldermans2Lingyun Jia3Department of Public Security Administration, Liaoning Police College, Dalian 116036, ChinaDalian Kangyuan Medical Technology Co., Ltd., Dalian 116014, ChinaDalian Kangyuan Medical Technology Co., Ltd., Dalian 116014, ChinaThe School of Bioengineering, Dalian University of Technology, Dalian 116036, ChinaInfectious diseases, caused by pathogenic microorganisms and capable of spreading, pose a significant threat to global public health. Developing efficient and cost-effective techniques for treating infectious diseases is crucial in curbing their progression and reducing patients’ morbidity and mortality. Nanobodies (Nbs), a novel class of affinity reagents derived from unique heavy chain-only antibodies in camelids, represent the smallest intact and fully functional antigen-binding fragments. Compared with conventional antibodies and their antigen binding fragments, Nbs offer numerous advantages, including high affinity, exceptional target specificity, cost-effective production, easy accessibility, and robust stability, demonstrating immense potential in infectious disease treatment. This review introduces Nbs and focuses on discussing their mechanisms and intervention strategies in the treatment of viral and bacterial infections.https://www.mdpi.com/2218-273X/15/5/610nanobodyinfectious diseasesvirusbacteriatreatment |
| spellingShingle | Wenning Jiang Chundong Huang Serge Muyldermans Lingyun Jia Small but Mighty: Nanobodies in the Fight Against Infectious Diseases Biomolecules nanobody infectious diseases virus bacteria treatment |
| title | Small but Mighty: Nanobodies in the Fight Against Infectious Diseases |
| title_full | Small but Mighty: Nanobodies in the Fight Against Infectious Diseases |
| title_fullStr | Small but Mighty: Nanobodies in the Fight Against Infectious Diseases |
| title_full_unstemmed | Small but Mighty: Nanobodies in the Fight Against Infectious Diseases |
| title_short | Small but Mighty: Nanobodies in the Fight Against Infectious Diseases |
| title_sort | small but mighty nanobodies in the fight against infectious diseases |
| topic | nanobody infectious diseases virus bacteria treatment |
| url | https://www.mdpi.com/2218-273X/15/5/610 |
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